Patents Represented by Attorney Thomas J. Bordner
  • Patent number: 6933137
    Abstract: Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times the level observed with batch fermentation. This process is used successfully to produce polysaccharides of N. meningitidis serotypes, A, C, Y and W-135 and is run reproducibly at the 20 L scale and can be scaled to 400 L or more.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: August 23, 2005
    Assignee: Aventis Pasteur
    Inventors: Richard C. Egen, Lori Ann Fortin, Willie Wei Qiang Sun