Patents Represented by Attorney, Agent or Law Firm Thomas J. DesRosier
  • Methods of inducing gamma interferon and stimulating blood cell populations using natural killer stimulatory factor
    Patent number: 5648072
    Abstract: Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: July 15, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Michiko Kobayashi, Gordon G. Wong, Rodney Hewick, Stanley F. Wolf
  • Therapeutic uses of IL-3
    Patent number: 5639453
    Abstract: A method of treating leukopenia, by administering an IL-3 polypeptide, is disclosed.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: June 17, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Steven C. Clark, Agnes B. Ciarletta, Yu-Chung Yang
  • DNA molecules encoding bone morpogenetic protein-11
    Patent number: 5639638
    Abstract: Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception, and for the induction of bone, cartilage and/or other connective tissue.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 17, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Anthony J. Celeste
  • DNA molecules encoding bone morphogenetic protein-10
    Patent number: 5637480
    Abstract: Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 10, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, John M. Wozney
  • BMP-15 compositions
    Patent number: 5635372
    Abstract: Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 3, 1997
    Assignees: Genetics Institute, Inc., Vanderbilt University
    Inventors: Anthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan
  • Bone morphogenic protein-5(BMP-5) and DNA encoding same
    Patent number: 5635373
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • Compositions comprising bone morphogenetic protein-2 (BMP-2)
    Patent number: 5631142
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: May 20, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • Arachidonic acid releasing phospholipase A2 enzyme and methods of use
    Patent number: 5622832
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 22, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • BMP-2 products
    Patent number: 5618924
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: April 8, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki Rosen
  • Pharmaceutical formulations of osteogenic proteins
    Patent number: 5597897
    Abstract: A composition comprising a pharmaceutically acceptable admixture of an osteogenic protein; a polymer matrix component selected from the group consisting of poly(lactic acid), poly(glycolic acid), and copolymers of lactic acid and glycolic acid; and an osteogenic protein-sequestering material.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: January 28, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Eyal Ron, Thomas J. Turek, Benjamin S. Isaacs, Himakshi Patel, Richard A. Kenley
  • Recombinant phospholipase A.sub.2 enzyme
    Patent number: 5593878
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Calcium independent cytosolic phospholipase A.sub.2 /B enzymes
    Patent number: 5589170
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: December 31, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Methods of treating preeclampsia
    Patent number: 5580554
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: December 3, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State University
    Inventor: James C. Keith
  • Use of interleukin-12 to prevent graft versus host disease
    Patent number: 5573764
    Abstract: The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: November 12, 1996
    Assignees: Genetics Institute, Inc., The General Hospital Corporation
    Inventors: Megan Sykes, Stanley F. Wolf
  • Methods of treating infection using natural killer stimulatory factor
    Patent number: 5569454
    Abstract: Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 29, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
  • Calcium independent cytosolic phospholipase A.sub.2 /B enzymes
    Patent number: 5554511
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: September 10, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Bone morphogenetic protein 5(BMP-5) compositions
    Patent number: 5543394
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: August 6, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • Methods of diagnosing and treating preeclampsia
    Patent number: 5543138
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 6, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State Univ.
    Inventor: James C. Keith
  • Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
    Patent number: 5536637
    Abstract: A novel method of screening for novel secreted mammalian proteins is described in which mammalian secretory leader sequences are detected using the yeast invertase gene as a reporter system.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: July 16, 1996
    Assignee: Genetics Institute, Inc.
    Inventor: Kenneth Jacobs
  • Recombinant phospholipase A.sub.2 enzyme
    Patent number: 5527698
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: June 18, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark