Patents Represented by Attorney Thomas J. Johnson

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  • Pyridinyl-quinolone compounds, their preparation and use
    Patent number: 5075319
    Abstract: Fluorinated 1-cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarbo xylic acids of the formula ##STR1## wherein R is hydrogen, R' and R" are hydrogen or fluoro, or other groups and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R=alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)pyridine.
    Type: Grant
    Filed: September 13, 1989
    Date of Patent: December 24, 1991
    Assignee: Sterling Drug Inc.
    Inventors: George Y. Lesher, Baldev Singh, Michael Reuman
  • Iodinated anilic acids
    Patent number: 4031088
    Abstract: 3-Amino-2,4,6-triiodobenzoic acids optionally substituted in the 5-position by amino or carboxy or a derivative thereof react with dibasic acid anhydrides to give the corresponding cyclic imides (A), which can be hydrolyzed to the corresponding anilic acids (B). The latter can be further alkylated on the anilide nitrogen atom. Compounds A and B are useful as cholecystographic and urographic agents.
    Type: Grant
    Filed: June 10, 1974
    Date of Patent: June 21, 1977
    Assignee: Sterling Drug Inc.
    Inventor: James H. Ackerman