Abstract: Retroviral vector production systems for producing lentivirus-based vector particles which are capable of infecting and transducing non-dividing target cells, wherein one or more of the auxiliary genes such as vpr, vif, tat, and nef in the case of HIV-1 are absent from the system. The systems and resulting retrovirus vector particles have improved safety over existing systems and vectors.
Type:
Grant
Filed:
July 25, 2001
Date of Patent:
December 30, 2003
Assignee:
Oxford Biomedica (UK) Limited
Inventors:
Alan John Kingsman, Susan Mary Kingsman, Narry Kim, Kyriacos Mitrophanous