Patents Represented by Attorney, Agent or Law Firm Thomas S. Diebert
  • Polynucleotides encoding staphylcoccal FAB I enoyl-ACP reductase
    Patent number: 6432670
    Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 13, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Payne, Peter Henry Milner, Stewart Campbell Pearson, John Timothy Lonsdale
  • FtsL
    Patent number: 6348579
    Abstract: The invention provides FtsL polypeptides and DNA (RNA) encoding FtsL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FtsL polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: February 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: John Edward Hodgson
  • Ups (ugc)
    Patent number: 6261802
    Abstract: The invention provides ups (ugc) polypeptides and polynucleotides encoding ups (ugc) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (ugc) polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Christopher M. Traini
  • Ribb
    Patent number: 6252044
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 26, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terance Black, Lisa Kathleen Shilling, Robert King Stodola, Richard Lloyd Warren, Anna Lisa Kosmatka, Richard Oakley Nicholas, Leslie Marie Palmer, Michael Arthur Lonetto, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles
  • RatA
    Patent number: 6207647
    Abstract: The invention provides ratA polypeptides and DNA (RNA) encoding ratA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: March 27, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, plc.
    Inventors: Michael Terence Black, Raymond W Reichard
  • 3-ketoacyl-ACP-reductase (FabG) of Staphylococcus aureus
    Patent number: 6110704
    Abstract: The invention provides fabG polypeptides and polynucleotides encoding fabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Damien McDevitt