Abstract: The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.
Type:
Grant
Filed:
March 14, 2005
Date of Patent:
June 14, 2011
Assignee:
Genetronics, Inc.
Inventors:
Robert J. Schwartz, Eric M. Eastman, Xuyang Li, Jeff Nordstrom
Abstract: The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular electrode system comprises a non-symmetrically arranged plurality of needle electrodes; a hypodermic needle; an electrical connector that provides a conductive link from a programmable constant-current pulse controller to the plurality of needle electrodes; and a power source. In a preferred embodiment of the present invention, an operator can grasp the plurality of needle electrodes that are mounted on a support structure and firmly insert the them into the selected tissue in a body or plant. The macromolecules are then delivered via the hypodermic needle into the selected tissue. The programmable constant-current pulse controller is activated and constant-current electrical pulse is applied to the plurality of needle electrodes.
Type:
Grant
Filed:
July 28, 2006
Date of Patent:
February 16, 2010
Assignee:
VGX Pharmaceuticals, Inc.
Inventors:
Allan Westersten, William R. Wilkinson, Ruxandra Draghia-Akli, Robert H. Carpenter, Douglas R. Kern
Abstract: This invention relates to prosthetic cardiac and venous valves and a single catheter device and minimally invasive techniques for percutaneous and transluminal valvuloplasty and prosthetic valve implantation.