Patents Represented by Attorney Thomas S. Szatkowski
  • Patent number: 6649756
    Abstract: The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[2R,3R)-2-({[(2S)-3-methyl-2-({[4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 18, 2003
    Assignee: Wyeth, Five Giralda Farms
    Inventors: Tarek Mansour, Phaik-Eng Sum, Yang-I Lin, Zhong Li
  • Patent number: 6645503
    Abstract: Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of the lipopolysaccharide, the conjugate eliciting a cross reactive immune response against heterologous strains of the gram negative bacteria.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: November 11, 2003
    Assignee: Wyeth Holdings Corporation
    Inventors: Rasappa G. Arumugham, Maria Fortuna-Nevin, Michael A. Apicella, Bradford W. Gibson
  • Patent number: 6635261
    Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: October 21, 2003
    Assignee: Wyeth Holdings Corporation
    Inventors: Vincent James LaPosta, John Hayward Eldridge
  • Patent number: 6306404
    Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Vincent James LaPosta, John Hayward Eldridge
  • Patent number: 5569762
    Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: October 29, 1996
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Michael P. Trova
  • Patent number: 5442059
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, and R.sup.1 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: August 15, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Patent number: 5430150
    Abstract: Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Robert E. Babine, Nan Zhang, Steven R. Schow, Allan Wissner
  • Patent number: 5428167
    Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: June 27, 1995
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Michael P. Trova
  • Patent number: 5407917
    Abstract: Methods for increasing the growth rate and increasing the efficiency of food utilization of meat-producing animals and for treating bacterial infections in said animals by administering an effective amount of selected antibiotics derived from the microorganism Streptomyces lydicus ssp. tanzanius (NRRL 18036) are described herein.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 18, 1995
    Assignee: American Cyanamid Company
    Inventor: Ian C. Hart
  • Patent number: 5405849
    Abstract: Novel quinazolinone compounds of the formula: ##STR1## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to alleviate angiotensin induced hypertension and treat congestive heart failure in mammals.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: April 11, 1995
    Assignee: American Cyanamid Company
    Inventors: Aranapakam M. Venkatesan, Jeremy I. Levin
  • Patent number: 5401863
    Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: March 28, 1995
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
  • Patent number: 5401729
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: March 28, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Patent number: 5381912
    Abstract: An improved child-resistant package allowing improved access and closure by the user is provided. The improved packages is of the press-and-turn type and features ramped gripping portions on the perimeter of the side of the press-and-turn cap and on the bottle.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: January 17, 1995
    Assignee: American Cyanamid Company
    Inventors: Linda A. Walker, Evan M. Hirsch
  • Patent number: 5380888
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: January 10, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Patent number: 5371076
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1, R.sup.2 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: April 2, 1993
    Date of Patent: December 6, 1994
    Assignee: American Cyanamid Company
    Inventors: Ving J. Lee, Brian L. Buckwalter, Timothy C. Barden
  • Patent number: 5369102
    Abstract: The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R.sup.1, R.sup.2, R.sup.3, X and Y defined hereafter as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: ##STR2## with R.sup.1, R.sup.2, Q, X and Y defined hereafter.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: November 29, 1994
    Assignee: American Cyanamid Company
    Inventors: Carl B. Ziegler, Jr., William V. Curran, Gregg Feigelson
  • Patent number: D359907
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventor: Evan M. Hirsch
  • Patent number: D359908
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid
    Inventor: Evan M. Hirsch
  • Patent number: D359909
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid
    Inventor: Evan M. Hirsch
  • Patent number: D359910
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventor: Evan M. Hirsch