Abstract: The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[2R,3R)-2-({[(2S)-3-methyl-2-({[4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor.
Type:
Grant
Filed:
July 9, 2001
Date of Patent:
November 18, 2003
Assignee:
Wyeth, Five Giralda Farms
Inventors:
Tarek Mansour, Phaik-Eng Sum, Yang-I Lin, Zhong Li
Abstract: Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of the lipopolysaccharide, the conjugate eliciting a cross reactive immune response against heterologous strains of the gram negative bacteria.
Type:
Grant
Filed:
March 9, 1999
Date of Patent:
November 11, 2003
Assignee:
Wyeth Holdings Corporation
Inventors:
Rasappa G. Arumugham, Maria Fortuna-Nevin, Michael A. Apicella, Bradford W. Gibson
Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
Type:
Grant
Filed:
August 30, 2001
Date of Patent:
October 21, 2003
Assignee:
Wyeth Holdings Corporation
Inventors:
Vincent James LaPosta, John Hayward Eldridge
Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
Type:
Grant
Filed:
July 13, 1999
Date of Patent:
October 23, 2001
Assignee:
American Cyanamid Company
Inventors:
Vincent James LaPosta, John Hayward Eldridge
Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, and R.sup.1 and W are defined in the specification. These compounds are useful as antibiotic agents.
Type:
Grant
Filed:
August 13, 1992
Date of Patent:
August 15, 1995
Assignee:
American Cyanamid Company
Inventors:
Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
Abstract: Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
Type:
Grant
Filed:
December 16, 1992
Date of Patent:
July 4, 1995
Assignee:
American Cyanamid Company
Inventors:
Michael P. Trova, Robert E. Babine, Nan Zhang, Steven R. Schow, Allan Wissner
Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
Abstract: Methods for increasing the growth rate and increasing the efficiency of food utilization of meat-producing animals and for treating bacterial infections in said animals by administering an effective amount of selected antibiotics derived from the microorganism Streptomyces lydicus ssp. tanzanius (NRRL 18036) are described herein.
Abstract: Novel quinazolinone compounds of the formula: ##STR1## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to alleviate angiotensin induced hypertension and treat congestive heart failure in mammals.
Type:
Grant
Filed:
October 29, 1993
Date of Patent:
April 11, 1995
Assignee:
American Cyanamid Company
Inventors:
Aranapakam M. Venkatesan, Jeremy I. Levin
Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
Type:
Grant
Filed:
March 29, 1994
Date of Patent:
March 28, 1995
Assignee:
American Cyanamid Company
Inventors:
Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
Type:
Grant
Filed:
February 24, 1994
Date of Patent:
March 28, 1995
Assignee:
American Cyanamid Company
Inventors:
Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
Abstract: An improved child-resistant package allowing improved access and closure by the user is provided. The improved packages is of the press-and-turn type and features ramped gripping portions on the perimeter of the side of the press-and-turn cap and on the bottle.
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
Type:
Grant
Filed:
March 2, 1994
Date of Patent:
January 10, 1995
Assignee:
American Cyanamid Company
Inventors:
Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1, R.sup.2 and W are defined in the specification. These compounds are useful as antibiotic agents.
Type:
Grant
Filed:
April 2, 1993
Date of Patent:
December 6, 1994
Assignee:
American Cyanamid Company
Inventors:
Ving J. Lee, Brian L. Buckwalter, Timothy C. Barden
Abstract: The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R.sup.1, R.sup.2, R.sup.3, X and Y defined hereafter as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: ##STR2## with R.sup.1, R.sup.2, Q, X and Y defined hereafter.
Type:
Grant
Filed:
July 6, 1993
Date of Patent:
November 29, 1994
Assignee:
American Cyanamid Company
Inventors:
Carl B. Ziegler, Jr., William V. Curran, Gregg Feigelson