Patents Represented by Attorney Thomas Szatkowski

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  • 7-(substituted)-8-(substituted)-9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5386041
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 31, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
    Patent number: 5338736
    Abstract: This disclosure describes novel 2,3,6-substituted quinazolinones of the formula: ##STR1## where R.sup.6, R.sup.5 and R are described in the specification which have activity as angiotensin II (AII) antagonists.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: August 16, 1994
    Assignee: American Cyanamid Company
    Inventor: Jeremy I. Levin
  • Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds using 10-formyltetrahydrofolate synthetase from clostridium
    Patent number: 5334535
    Abstract: A process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds is described, comprising the conversion, for example, of only the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolate synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative of (radiolabeled) tetrahydrofolic acid or a salt or ester thereof.
    Type: Grant
    Filed: September 18, 1992
    Date of Patent: August 2, 1994
    Assignee: American Cyanamid Company
    Inventors: Gerhard Schlingmann, Stuart A. Rosenfeld