Patents Represented by Attorney Thomas Triolo

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  • Methods of inhibiting metastasis
    Patent number: 6949243
    Abstract: Methods of inhibiting metastasis or maintenance of various cancers are provided. In particular, the method makes use of fact that certain trafficking of cancers depend upon identified proteins, which serve as markers. Additional methods of screening are also provided.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 27, 2005
    Assignee: Schering Corporation
    Inventors: Anja Mueller, Albert Zlotnik
  • Single-chain recombinant complexes of hepatitis C virus NS3 protease and NS4A cofactor peptide
    Patent number: 6653127
    Abstract: Covalent HCV NS4A-NS3 complexes comprising the central hydrophobic domain of native HCV NS4A peptide, a linker, and the HCV NS3 serine protease domain, wherein the hydrophobic domain of native HCV NS4A peptide is tethered by the linker to the amino terminus of the HCV NS3 protease domain.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: November 25, 2003
    Assignee: Schering Corporation
    Inventors: Bruce A. Malcolm, S. Shane Taremi, Patricia C. Weber, Nanhua Yao
  • Crystallizable farnesyl protein transferase compositions, crystals thereby obtained, and methods for use
    Patent number: 6539309
    Abstract: The present invention relates to compositions and crystals of farnesyl protein transferase and farnesyl protein transferase in complex with substrates and inhibitors. Also disclosed are crystallization conditions for these compositions and their use for structural determination of FPT:FPP/FPP analog:peptide/inhibitor complexes.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: March 25, 2003
    Assignee: Schering Corporation
    Inventors: Corey Strickland, Zhen Wu, William T. Windsor, Patricia C. Weber
  • Crystalline farnesyl protein transferase compositions and methods for use
    Patent number: 6535820
    Abstract: The present invention relates to crystalline compositions comprising farnesyl protein transferase-like polypeptides in complex with substrates and inhibitors. Also disclosed are crystallization conditions for these compositions and their use for structural determination of FPT:FPP/FPP analog: peptide/inhibitor complexes.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: March 18, 2003
    Assignee: Schering Corporation
    Inventors: Corey Strickland, Patricia C. Weber