Abstract: The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and also insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention includes the use of the vectors in introducing genes into cells, in making vaccines and in gene therapy.
Type:
Grant
Filed:
May 31, 1994
Date of Patent:
October 31, 2000
Assignee:
AdVec, Inc.
Inventors:
Frank L. Graham, Andrew Bett, Ludvik Prevec, Wael M. Haddara
Abstract: The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 19, 2000
Assignee:
AdVec, Inc.
Inventors:
Frank L. Graham, Martina Anton, Silvia Bacchetti, Ping Wang, Michael A. Rudnicki, William J. Muller
Abstract: An interference screw is provided by machining a fragment of autograft or allograft cortical bone from a donor or from a recipient's amputated bone. The interference screw has a cortical surface into which a self-tapping thread is machined. The interference screw has a machined pointed, rounded or flush end and an opposite machined end which mates with a drive means, and has advantages over conventional interference screws known in the art in that subsequent to implantation, no residual hardware that must later be removed remains at the implant site.
Type:
Grant
Filed:
June 17, 1998
Date of Patent:
April 4, 2000
Assignee:
University of Florida Tissue Bank, Inc.
Inventors:
James N. Grooms, Kevin Carter, David H. Dulebohn