Patents Represented by Attorney Timothy J. Lithgow
  • Patent number: 5437861
    Abstract: This invention provides a composition, device and method for the treatment or prevention of septic shock syndrome or other conditions evidenced by the presence of cytokines in a patient by contacting the patient's whole blood with a composition comprising silica and a surface treatment material, such as heparin, but preferably human serum albumin (HSA). The treatment lowers the cytokine concentration of the blood.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: August 1, 1995
    Assignee: Applied Immune Sciences, Inc.
    Inventors: Thomas B. Okarma, John Blankenship, Abraham T. Lin, Mohammad A. Elkalay
  • Patent number: 5301692
    Abstract: A technique for immediate, total breast reconstruction is described that equally preserves the skin of both the mastectomy and remaining breast. The technique is most applicable to a mastectomy which is performed through a circumareolar incision. Replacement tissue for the excised nipple-areolar complex is provided by a latissimus dorsi flap having a cutaneous peg. The pectoralis major and latissimus dorsi flap serve to create a submuscular prosthetic compartment. The submuscular compartment, together with the volume of the latissimus dorsi flap, closely approximates the volume of the contralateral breast, and the normal contour of the breast skin envelope. Accordingly, insertion of a permanent implant instead of an expander is possible. The nipple-areolar reconstruction can also be completed at the initial operative stage.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: April 12, 1994
    Inventor: Edward W. Knowlton
  • Patent number: 5283034
    Abstract: A method and composition which permits sterilization of surfaces coupled with biologically active moieties by ionizing radiation is described. The protecting composition contains a surface-stabilizing agent which adheres to the surface and has a molecular weight.gtoreq.5 kd, and an oxygen radical scavenger which is preferably a di- or polysaccharide or reduced form thereof. In the method of the invention, a surface which is coupled to a biologically active agent is protected with the invention composition, dried to a moisture content of less than 1%, and then sterilized by ionizing radiation under standard conditions. The sterilized surfaces of the invention are particularly useful in the production of medical devices intended for extracorporeal use, particularly in cell-separation techniques.
    Type: Grant
    Filed: March 26, 1992
    Date of Patent: February 1, 1994
    Assignee: Applied Immune Sciences, Inc.
    Inventors: David A. Okrongly, Donald Lamons, Thomas B. Okarma