Abstract: A method of acylating C-2' O-protected-10-hydroxy taxol selectively at the C-10 hydroxyl position over the C-7 hydroxy position thereof to produce C-2' O-protected taxol is accomplished first by dissolving C-2' O-protected-10-hydroxy taxol in an acceptable ether solvent therefor, such as tetrahydrofuran. A lithium salt, preferably lithium chloride, is added. A trialkylamine base or pyridine is next added, followed by the addition of an acylating agent, such as acetyl chloride. The resulting solution may be quenched, for example with ammonium chloride, to eliminate excess of the acylating agent. This solution may then be diluted with ethyl acetate to form an organic phase and an aqueous phase, with the organic phase being washed and thereafter reduced. Recrystallization and column chromatography may be employed to purify the C-2' O-protected taxol.

Abstract: A method and apparatus for seaming a lid onto a container body by moving the body with a lid placed thereon in a linear fashion by allowing free rotation of the conveyed container body and lid against a linear seaming element is disclosed.

Abstract: A jaw retention device operative for use by a dental patient to urge the patient's lower jaw into an open position thereby relieving stress on the jaw muscles during dental procedures. The device includes a hand held object connected by an elongated flexible member to a mouth piece. The mouth piece is preferably constructed of a plastic material having sufficient flexibility to permit the mouth piece to bend and release from the lower teeth when the flexible member is subjected to a selected threshold tension.

Abstract: A door latch actuator operates a latch bolt assembly of a door. The door latch actuator employs a spring latch plunger and a dead latch plunger mounted in a housing that has a latch cavity sized to receive the spring latch bolt and the dead latch bolt pin. The spring latch plunger engages and retracts under the pressure of the spring latch bolt, and the dead latch plunger engages the dead latch bolt pin. A drive operates the plungers to first withdraw the dead latch plunger to allow the dead latch bolt pin to move to an enabling position for the spring latch bolt. Next, the drive advances the spring latch plunger and thereby the spring latch bolt in moved to a release position and the door may be opened. The drive is preferably a rotary drive using a motor driven crank and pin system. Sensors are provided to detect the position of the system. The method of the invention encompasses the operative steps of this door latch actuator, and the method can include timing steps.

Abstract: A keyboard with a cursor control device and a palm support which supports the palms while allowing the fingers to be placed in the typing position. The palm support is connected to the cursor control device which allows the user to maintain the fingers in the typing position while controlling the position of the cursor on the display screen with palm movements.

Abstract: An apparatus and method for monitoring pressure between the surface of a body part and a contact surface employ a plurality of pressure sensors disposed in a matrix array between the contact surface and the body part. The sensors produce analog force signals proportional to pressure, and a monitor receives the analog signals and produces output signals, preferably digital, having pressure data corresponding to the pressure at each sensor. A computer processor receives the output signals from the monitor to create a force profile for the sensor array. The sensors may be scanned as a read event in variety of manners, including periodic, continuous and triggered scanning. Where triggered scanning is desired, one or more switches act to initiate a read event. This monitoring apparatus and method is used, for example, to fit prosthetics, to monitor bed-ridden and wheelchair-bound patients, to reduce pain and sores caused by uneven distribution of pressure and to monitor pressure between a cast and a person.

Abstract: A lock box assembly is mountable to a vehicle to receive an item to be protected and to affix a license plate thereto. The lock box apparatus comprises an elongated housing formed by an anchoring plate and a door and having an interior sized to receive the protected item. The anchoring plate has a pair of anchoring holes that are alignable with installation holes on the vehicle so that the anchoring plate may be mounted to the vehicle. The door is pivotally mounted to the anchoring plate between a closed position enclosing the interior and preventing access to the protected item and an opened position exposing the interior and permitting access to the protected item. The door is provided with a pair of door holes registerable with cooperative holes in the license plate so that the license plate may be affixed thereto.

Abstract: A chemical compound having the formula: wherein R is an alkyl group and M.sup.+ counterion is an alkali metal, and a process of making the same.

Abstract: A spectrophotometer measures optical absorption of light by a sample received in a sample cell. An array of optical elements disperses the light over a spectral pattern, and a fiber optic beam splitter splits light at a selected spectral band into a reference component and a test component. Detectors measure the intensity of the reference component and the test component after the test component passes through the sample. The fiber optic beam splitter includes a plurality of strands arranged with first ends terminating in a common circular area. Opposite ends of peripheral strands are collected into a first set that transmits the test component while the remaining strands for a second set that transmits the reference component. Preferably, there is a single, central, large strand surrounded by smaller strands. Two emitters are provided for light of two different types, such as visible and UV. The optical array forms a collimated beam having an inner core of one type of light and an outer shell of the other.

Abstract: A storage unit includes frame pieces that attach to a support structure. A first rail assembly has first rails disposed on the frame pieces so that facing channels define a storage region. A drawer is positioned in the storage region when in a stored state. A second rail assembly includes second rails each having a second channel. The second channels receive first wheels that are on the first rail assembly while the first channels receive second wheels that are disposed on the second rail assembly. The drawer may be advanced out of the stored state to an extended state and then into a pivoted state wherein it is perpendicular to the stored state. The rails may be immovably fixed to the frame pieces and the drawer, respectively. The drawer may be mounted underneath the support structure. Arcuate guide fingers guide the engagement and disengagement of the first wheels from the second channels when the drawer is moved between the extended and pivoted states.

Abstract: Security box apparatus is adapted for use with a conventional license plate mounting structure of a vehicle which includes a plurality of spaced apart installation holes. The security box apparatus is adapted to affix a license plate thereto to secure a protected item and comprises a housing member, a door, a locking structure and a license plate mounting assembly. The housing member is provided with a plurality of anchoring holes alignable with the installation holes so that a mounting fastener may extend through these holes to securely fasten the housing member to the license plate mounting structure. A recess is formed in the housing member and the door is sized and adapted to be received in this recess to enclose the interior and the protected item. The door is movable between a closed position wherein access to the interior is prevented and an opened position wherein access to the protected item is permitted.

Abstract: An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.

Abstract: The present invention provides a method of producing a protective device that is adapted for use with a container in order to inhibit ingress of unwanted materials through a handhold opening in a wall of the container. The method includes a first step of advancing a first strip of material in a longitudinal direction from an upstream location to a downstream location. As this first strip of material is advanced, it is longitudinally scored after which a second strip of material is secured to the first strip of material such that the second strip is sealed around a discrete consecutive portion of the scoring. Thereafter, an adhesive material is applied to a side surface of the first strip opposite the second strip. The joined first and second strips are then cut into individual units with portions of the first and second strips in each unit being sealed completely around the periphery thereof.

Abstract: A method of maximizing system operating pressure capability of a selected flange joint in a fluid carrying pipeline system comprises minimizing bold load operating conditions and bolt load pre-load conditions at the selected flange joint by interposing a self-energizing seal assembly having negligible "m" and "y" values in surrounding relation to the joint's axial bore. The load producing moment resulting from connection of the flanges with the bolts is minimized by interposing a gasket element having a gasket thickness less than the seal thickness of the self-energizing seal assembly. The gasket element is interposed in a surrounding relation to the seal assembly at an outer radial location proximate to the outer flange surface margin.

Abstract: A carton is disclosed adapted to package a plurality of items for shipment, especially laptop computers and accessories. The carton includes a sidewall, end closures formed by plurality of flaps, and a shelf assembly forming compartments in the carton. The shelf assembly includes a shelf panel, support pieces secured to the sidewall, and a spacer panel. A lip piece hinged to the spacer panel engages the sidewall to permit selective positioning of the spacer panel in different closed positions to accommodate differently sized contents.

Abstract: A glide head device for attachment to a flexure and for operation with a test system to detect a presence of asperities on a moving surface includes a slider constructed as a rigid body that is adapted to be suspended from the flexure and a transducer operatively associated with the slider. The slider's rigid body includes an air bearing surface operative to be oriented in facing relation to the moving surface when in an operative state and a sidewall margin area adjacent the trailing edge which is microfinished to a selected Ra value, such as 200 angstroms. A glide head assembly and a test device incorporating such a glide head device are also provided.

Abstract: An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process includes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.

Abstract: A bi-directional impact tool includes a hollow tube member and a shaft slidably received by the hollow tube member in a telescopic relationship. The hollow tube member extends along a longitudinal axis and has a first end and a second end disposed opposite the first end. The shaft extends longitudinally along the longitudinal axis and has a working end disposed exteriorly of the hollow tube member for engaging the workpiece and a striking end disposed opposite the working end and interiorly of the hollow tube member. Moving the hollow tube member in a first direction so that the first end collides with the striking end while the working end is engaged with the workpiece imparts a first impact force to the workpiece in the first direction. Moving the hollow tube member in a second direction opposite the first direction so that the second end collides with the striking end while the working end is engaged with the workpiece imparts a second impact force to the workpiece in the second direction.

Abstract: A canopy structure, kit and method permits a user to custom configure a canopy shelter is almost unlimited curvilinear shapes. To accomplish this, a flexible sheet that is elastic in at least one, but preferably two dimensions may be secured over an area to be sheltered. Anchors connect the sheet either directly to the surface, such as the ground, or to an object, such as a tree or building, secured to the surface. A support pole is interposed between the surface and the sheet; and this support pole is sufficiently long to deform the sheet in the direction(s) of elasticity and thus exert a compression force on the pole. A plurality of support poles of varying lengths may be formed from identical pole sections, and base plates and dome elements may be used on the poles. The anchors are formed to engage the edge margin of the sheet at random locations, and these anchors, or alternative clasps, may engage the central portion of the sheet so that even greater design flexibility is possible.