Patents Represented by Attorney Timothy L. McCutcheon

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  • Modified luciferase protein
    Patent number: 8206961
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: June 26, 2012
    Assignee: Marker Gene Technologies, Inc.
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • Modified luciferase gene and protein
    Patent number: 7723502
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: May 25, 2010
    Assignee: Marker Gene Technologies, Inc
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook