Patents Represented by Attorney Timothy R. Howe

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  • Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
    Patent number: 6146902
    Abstract: Disclosed and claimed are a method for the purification of polysaccharide-protein conjugate vaccines by ultrafiltration in a saturated solution of ammonium sulfate. The ultrafiltration method of the present invention provides an efficient, readily scalable method for removal of unbound polysaccharides from polysaccharide-protein vaccines, thereby improving the purity and consistency of the polysaccharide-protein vaccines.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: November 14, 2000
    Assignee: Aventis Pasteur, Inc.
    Inventor: Ronald McMaster
  • Potentiation of immunogenic response
    Patent number: 6024963
    Abstract: An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physio-chemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: February 15, 2000
    Assignee: Connaught Laboratories, Inc.
    Inventors: Robert S. Becker, Karen Biscardi, Laura Ferguson, Lorne Erdile
  • Formyl methionyl peptide vaccine adjuvant
    Patent number: 6017537
    Abstract: The present invention relates to immunological adjuvants comprised of the N-formyl methionyl peptide fMLP. FMLP, when used as an adjuvant in accordance with the present invention, provides for an immune response to suboptimal doses of recombinant antigens.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: January 25, 2000
    Assignee: Connaught Laboratories, Inc.
    Inventors: Jeannine Alexander, William I. Cox
  • Method for the covalent attachment of polysaccharides to protein molecules
    Patent number: 5965714
    Abstract: Disclosed and claimed are a method for the covalent attachment of poly- and oligosaccharides to protein molecules via hydrogen peroxide depolymerization of the polysaccharide units, followed by attachment of the depolymerized polysaccharide chain to the amino acid groups of a protein of interest through a linker molecule, and products therefrom, and methods for using the products.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: October 12, 1999
    Assignee: Connaught Laboratories, Inc.
    Inventor: Robert P. Ryall