Patents Represented by Attorney Todd E. Wiggin & Dana Garabedian
  • Patent number: 6162446
    Abstract: Disclosed is a personal care composition comprising: (a) water or an alcohol, (b) at least one dispersant or surfactant, and (c) as an antimicrobial or preservative additive, particles of an in-situ transchelation reaction product of a zinc compound selected from the group consisting of zinc salts of organic acids, zinc salts of inorganic acids, zinc hydroxide, zinc oxide, and combinations thereof, said zinc compound being soluble in said water or alcohol, with pyrithione acid or a pyrithione salt that is soluble in said water or alcohol. Also disclosed is a process for preparing the personal care composition, and a coated substrate containing a coating of the personal care composition.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: December 19, 2000
    Assignee: Arch Chemicals, Inc.
    Inventors: Rahim Hani, George A. Polson
  • Patent number: 6136460
    Abstract: A method of introducing an anti-tarnish agent into the matrix of a tin coating to reduce oxidation and/or yellowing of the tin coating. The agent is preferably zinc, indium or phosphorous and can be deposited in a molten form to alloy with the existing tin coating. Alternatively, the existing tin coating may be exposed to a chemical bath including the agent and later heated to reflow the tin coating and agent thereby incorporating the agent into the matrix of the tin coating.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: October 24, 2000
    Assignee: Olin Corporation
    Inventors: Szuchain Chen, Julius Fister, Dennis Brauer, Arvind Parthasarathi, Christopher Laurello
  • Patent number: 6100398
    Abstract: Disclosed is a process for the preparation of N-aryl amine compounds, comprising reacting an amine compound with an arylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-aryl amine compound, the transition metal catalyst comprising a Group 8 metal and P(t-Bu).sub.3 as a ligand, and wherein the ratio of the ligand to the Group 8 metal is in the range of about 3:1 to about 0.25:1, and wherein the reaction temperature is less than 100.degree. C. The process of the present invention provides a useful general method of N-arylation for the manufacture of pharmaceuticals, polymers, and the like.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: August 8, 2000
    Assignee: Yale University
    Inventors: John F. Hartwig, Motoi Kawatsura, Sheila I. Hauck, Kevin H. Shaughnessy, Luis M. Alcazar-Roman
  • Patent number: 6078239
    Abstract: A high-frequency transformer, comprises: a ring core made of amorphous magnetic material; a core protection box made of conductive material and enclosing the ring core; and a high-voltage winding, consisting of enamel-insulated wire wound on the core protection box. Wherein, on the ring top wall of the core protection box there is a ring gap in the peripheral direction, and at inner fringe and outer fringe of the ring gap, a plurality of leading wires are respectively arranged in the peripheral direction. The leading wires at inner fringe and outer fringe of the ring gap are electrically-connected together respectively and form two terminals. The core protection box and the two terminals constitute low-voltage winding of the high-frequency transformer. If the low-voltage winding comprises two or more core protection boxes, it can have a central tap or have multi-turn. A thus fabricated high-frequency transformer has a smaller size, a lighter weight and is more apt to industrial batch manufacture.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: June 20, 2000
    Assignees: Suzhen Hu, Li Zhang
    Inventor: Suzhen Hu
  • Patent number: 6057456
    Abstract: The present invention is directed to a process for preparing alpha-arylated carbonyl-containing compounds, comprising the steps of reacting a compound having at least one carbonyl group with an arylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an alpha-arylated carbonyl-containing compound, the transition metal catalyst comprising a Group 8 metal and at least one chelating ligand selected from the group consisting of unsaturated Group 15 heterocycles, Group 15-substituted metallocenes, Group 15-substituted alkanes, Group 15-substituted arylenes, and combinations thereof. The process of the present invention simplifies the preparation of commercially significant organic alpha-aryl carbonyl-containing compounds, particularly for use in the pharmaceutical and polymer industries.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: May 2, 2000
    Assignee: Yale University
    Inventors: John F. Hartwig, Blake C. Hamann
  • Patent number: 6040338
    Abstract: The present invention relates to a compound of the formula wherein R.sup.1 and R.sup.2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R.sup.3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R.sup.4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: March 21, 2000
    Assignee: Yale University
    Inventors: Alan C. Sartorelli, Krishnamurthy Shyam, Philip G. Penketh, Shu-Hui Chen
  • Patent number: 6024889
    Abstract: The invention is directed to a chemically active fire suppression composition, comprising a propellant comprising a fuel and an oxidizer, the propellant capable of generating inert gas; and an environmentally innocuous chemical fire suppressant capable of generating fire suppressive reactive species. The combination of physically acting fire suppression agents and chemically acting, environmentally innocuous fire suppression agents results in a highly effective, environmentally innocuous fire extinguishing composition that has low ozone depletion potential (ODP), low global warming potential (GWP), and high suppression efficiency.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: February 15, 2000
    Assignee: Primex Technologies, Inc.
    Inventors: Gary F. Holland, Michael A. Wilson
  • Patent number: 6017562
    Abstract: The present invention relates to non-spherical and/or non-platelet pyrithione particles. Also disclosed is a method for producing non-spherical and/or non-platelet particles of pyrithione salts, comprising reacting pyrithione or a water-soluble salt of pyrithione and a water-soluble polyvalent metal salt in the presence of a dispersant at a temperature from about 20.degree. C. to about 60.degree. C. to produce non-spherical and/or non-platelet particles of pyrithione salts. The present invention further relates to particles made by the above methods and products, such as shampoos, soaps, and skin-care medicaments made using these particles.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: January 25, 2000
    Assignee: Arch Chemicals, Inc.
    Inventors: Charles W. Kaufman, Saeed H. Mohseni, John J. Jardas, George A. Polson, David C. Beaty
  • Patent number: 5977361
    Abstract: The present invention is directed to a process for the preparation of N-aryl compounds containing at least one unsaturated nitrogen atom, comprising reacting a compound having at least one unsaturated nitrogen atom with an arylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-aryl compound containing at least one unsaturated nitrogen atom, wherein the aryl moiety of the N-aryl compound is bonded to the at least one unsaturated nitrogen atom, the transition metal catalyst comprising a Group 8 metal and at least one chelating ligand selected from the group consisting of Group 15-substituted metallocenes, Group 15-substituted arylenes, unsaturated Group 15 heterocycles, Group 15-substituted alkanes, and combinations thereof. The process of the present invention a useful general method of N-arylation for the manufacture of pharmaceuticals, polymers, and the like.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: November 2, 1999
    Assignee: Yale University
    Inventors: John F. Hartwig, Grace Mann
  • Patent number: 5960894
    Abstract: The invention is directed to an expendable tubing conveyed perforator, comprising (a) an outer tube made from a material having high strength and low impact resistance; and (b) an inner structure positioned within the outer tube for holding one or more explosive charges, the inner structure made from a combustible material. The invention is also directed to a method of perforating a well casing using the expendable tubing conveyed perforator system.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: October 5, 1999
    Assignee: Primex Technologies, Inc.
    Inventors: Terry G. Lilly, Leslie E. Noel, Edwin G. Steiner, William Kamper
  • Patent number: 5962807
    Abstract: The present invention is directed to a pre-molded aft seal for an armor piercing fin stabilized discarding sabot (APFSDS) projectile, comprising a plastic sleeve made from a material selected from the group consisting of thermoplastic polyurethane and thermoplastic polyester elastomer, and effective to seal an APFSDS projectile from combustion products, the plastic aft sleeve further comprising an outwardly flanged first portion having a radius of curvature of from about 0.1 to 5 inches; a constantly decreasing diameter second portion; and an inwardly flanged substantially conical third portion connected to the second portion by a curved portion having a radius of curvature of from about 0 to 0.25 inch.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: October 5, 1999
    Assignee: Primex Technologies, Inc.
    Inventors: William B. Stewart, Donald R. Osment, John W. Duchek
  • Patent number: 5958710
    Abstract: This invention relates to a novel estrogen receptor-related nuclear receptor, hereinafter termed "ER.beta." having the amino acid sequence of FIGS. 1, 13A or 14A or substantially the same ambino acid sequence as the amino acid sequence shown in FIGS. 1, 13A or 13B or an amino acid sequence functionally similar to that sequence. The invention also relates to DNA sequences encoding the receptor. The receptor may be useful in isolating molecules for the treatment of disorders such as prostate cancer, benign prostatic hyperplasia, osteoporosis or cardiovascular disorders and in the testing of substances for estrogenic and other hormonal effects.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: September 28, 1999
    Assignee: Karo Bio AB
    Inventors: Georg Kuiper, Eva L. K. Enmark, Jan-Ake Gustafsson
  • Patent number: 5929132
    Abstract: This invention relates to a process improvement for preparing a storage-stable dispersion of a biocide which comprises the steps of: (a) dispersing a solid biocide and a carrier to form a biocide concentrate, (b) heating said biocide concentrate to an elevated temperature to provide a storage stable mixture of biocide, resin and carrier, and (c) cooling said mixture under continuous stirring to provide a homogeneous, storage-stable liquid dispersion. Also claimed is the storage-stable product produced by this process.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: July 27, 1999
    Assignee: Arch Chemicals, Inc.
    Inventors: Rahim Hani, Cynthia M. Ward
  • Patent number: 5873734
    Abstract: In one aspect, the present invention is directed to a kit for constructing a biomechanical model of a lever system selected from a first class lever system, a second class lever system, and a third class lever system, comprising a base, a support structure attachable to the base, at least one lever assembly attachable to the support structure, and at least one cord assembly attachable to the lever assembly. The present invention is also directed to first, second and third class lever system models useful for teaching and demonstration purposes.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: February 23, 1999
    Assignee: The Science Learning Workshop, Inc.
    Inventors: Joseph G. Griswold, Daniel E. Lemons
  • Patent number: 5866842
    Abstract: A low temperature autoigniting composition for use in a mobile occupant restraint system comprising, a low temperature melting oxidizer and a fuel, wherein the low temperature autoigniting composition autoignites in the temperature range of about 130.degree. C. to about 175.degree. C. In a preferred embodiment, the composition comprises a low temperature melting oxidizer, a fuel, and a catalyst, wherein the composition autoignites in the temperature range of about 130.degree. C. to about 150.degree. C. Preferably, the oxidizer comprises about 20 to about 70 percent by weight of the composition, the fuel comprises about 10 to about 50 percent by weight of the composition, and the catalyst comprises about 2 to about 50 percent by weight of the composition. The autoignition propellants of the invention are designed to function at low temperatures and before heat damage to an airbag deployment mechanism can occur, for example, during a fire.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: February 2, 1999
    Assignee: Primex Technologies, Inc.
    Inventors: Kimberly A. Wilson, Michael A. Wilson, Donald R. Poole, Gary F. Holland
  • Patent number: 5858357
    Abstract: The invention is directed to a pharmaceutical preparation with a modulatory effect on malignant tumors, which contains a combination of protease proenzymes and amylases in a ratio between 1:100 and 100:1 in enzymatic activity units, and a protease inhibitor. The invention is also directed to use of such a preparation to modulate the effects of malignant tumors in humans and animals.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: January 12, 1999
    Inventors: Frantisek Trnka, Miroslav Rybak, Roman Marek, Ladislav Vavra
  • Patent number: 5854266
    Abstract: Disclosed herein is an antimicrobial composition characterized by synergistic antibacterial efficacy against Gram-negative bacteria and comprising an antimicrobially effective amount of a pyrithione salt or pyrithione acid, and an alcohol, preferably an aromatic alcohol. Also disclosed is a method of imparting antimicrobial activity to a composition comprising water or an organic solvent which comprises adding thereto an antimicrobially effective amount of the above-described antimicrobial composition.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 29, 1998
    Assignee: Olin Corporation
    Inventor: John D. Nelson, Jr.
  • Patent number: 5854282
    Abstract: The invention provides compounds according to the formula ##STR1## in which: Ha=I or BrX=CH.sub.2 or C=OR.sup.1 =C.sub.1-4 alkylR.sup.2 =--NHSO.sub.2 R.sup.3 ;--NHCOR.sup.3 ; or--NHCONHR.sup.3where R.sup.3 =--CF.sub.3,C.sub.1-3 alkyl, 4-R.sup.4 C.sub.6 H.sub.4 --;where R.sup.4 =C.sub.1-4 alkoxy-; hydroxy-; fluoro-; or nitro-;or a pharmaceutically acceptable salt thereof.The compounds may particularly be used in the treatment of T3 regulated gene disorders and diseases.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: December 29, 1998
    Assignee: Karo Bio AB
    Inventor: Charlotta Mellin
  • Patent number: 5789699
    Abstract: The invention is directed to a sabot having a longitudinal axis and comprising a plurality of sabot segments. Each of the sabot segments comprises a repeating structure of:(a) a plurality of plies of a first fibrous material oriented radially from the longitudinal axis, wherein each fiber of the first fibrous material is oriented substantially parallel to the longitudinal axis; and(b) a plurality of plies of a second fibrous material, wherein each fiber of the second fibrous material is oriented nonparallel to the longitudinal axis and substantially parallel to every other fiber of the second fibrous material. The total number of plies in each repeating structure is at least five (5). The invention is also directed to an APFSDS kinetic energy tank projectile that utilizes the above-described sabot.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: August 4, 1998
    Assignee: Primex Technologies, Inc.
    Inventors: William Brian Stewart, Donald Richard Osment
  • Patent number: 5777178
    Abstract: The present invention is directed to a process for the preparation of polyoxyalkylene ether surfactant compositions comprising the steps of combining an admixture of alkoxylated alcohols with an acid catalyst and 1-6 molar equivalents of an aldehyde. The mixture is reacted at between about 50.degree. C. and about 180.degree. C. and at between about 1 atm and 10 atm pressure in the absence of a distillation step to produce the polyoxyalkylene ether surfactant composition.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: July 7, 1998
    Assignee: Olin Corporation
    Inventor: Ming Shen