Patents Represented by Attorney Todd Spalding
  • Patent number: 8124356
    Abstract: The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: February 28, 2012
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Darrell C. Conklin
  • Patent number: 7795392
    Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: September 14, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Todd G. Kirchgessner, Bonnie Hsiang, Yingjie Zhu, Yuli Wu, Zhaoqing Wang, Jean S. Lynch, Xin Huang, Wen-Pin Yang
  • Patent number: 7259000
    Abstract: The present invention relates to a chimeric chemokine receptor comprising two components: a first sequence comprising the N terminus through the last residue of the seven helix TM region of a first chemokine receptor joined with a second sequence comprising the C terminus of a second chemokine receptor extending from the first intracellular residue of the chemokine receptor to the last residue of the chemokine receptor. The chimeric chemokine receptor can be employed in various applications, such as ligand binding and screening assays and signalling assays. The chimeric chemokine receptor can also form a component of a chemokine receptor modulator design program.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: August 21, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph E. Dinchuk, Paul Davies, Qihong Zhao, Percy H. Carter, Kimberly A. Solomon, Peggy Ann Scherle