Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
Type:
Grant
Filed:
July 6, 2006
Date of Patent:
November 27, 2012
Assignee:
Advanced Technologies and Regenerative Medicine, LLC
Inventors:
Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Anna Gosiewska
Abstract: HIV replication inhibitors of formula wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and X have specific definitions, and pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions.
Type:
Grant
Filed:
December 28, 2007
Date of Patent:
November 27, 2012
Assignee:
Janssen R&D Ireland
Inventors:
Jerôme Emile Georges Guillemont, Céline Isabelle Mordant, Benoit Antoine Schmitt
Abstract: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
Type:
Grant
Filed:
April 24, 2009
Date of Patent:
October 2, 2012
Assignee:
Advanced Technologies and Regenerative Medicine, LLC
Inventors:
Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
Abstract: The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
Type:
Grant
Filed:
September 10, 2004
Date of Patent:
September 18, 2012
Assignee:
Janssen R&D Ireland
Inventors:
Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri
Abstract: Asphalt/polymer fibers include, by weight, 30% to 85% polymeric material and 15% to 70% asphaltic material, where the polymeric material has a melt flow index of no more than about 35 grams/10 minutes. Preferably, the combination of polymeric material and asphaltic material has a melt flow index of from 80 grams/10 minutes to 800 grams/10 minutes. The asphaltic material is preferably asphalt having a softening point of from 82.degree. C. to 177.degree. C. The polymeric material is preferably a polymer selected from polypropylene, polyethylene, polystyrene, polyesters, ethylene copolymers, acrylates, methacrylates, and mixtures of these polymers. The organic fibers of asphalt/polymer may be intermingled with mineral reinforcing fibers and formed into products such as mats.
Type:
Grant
Filed:
August 5, 1996
Date of Patent:
January 27, 1998
Assignee:
Owens-Corning Fiberglass Technology, Inc.