Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
Type:
Grant
Filed:
November 28, 2000
Date of Patent:
September 27, 2005
Assignee:
Epoch Pharmaceuticals, Inc.
Inventors:
Robert O. Dempcy, Irina A. Afonina, Michael J. Singer, Igor V. Kutyavin