Abstract: The present invention provides for a leg exerciser device offering a pair of footplates arranged for inward and outward reciprocal movement along a respective pair of rails and whereby each of the footplates is operatively connected by way of support arms to a variable number of weights so as to increase the resistance offered by apparatus during an exercise routine. The path of travel of each footplate and the configuration of each arm is such that the vertical distance moved by the weights is greater than the vertical distance moved by each footplate during its reciprocal motion along the rails so as to enhance the degree of work undertaking during an exercise routine.

Abstract: The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of suffering, toxic effects of verotoxin.

Abstract: A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron the method comprising administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor neuronal protein. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity and ischemic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95/NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults and dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia.

Abstract: A technique for forming a film of material (12) from a donor substrate (10). The technique has a step of introducing energetic particles (22) through a surface of a donor substrate (10) to a selected depth (20) underneath the surface, where the particles have a relatively high concentration to define a donor substrate material (12) above the selected depth. An energy source is directed to a selected region of the donor substrate to initiate a controlled cleaving action of the substrate (10) at the selected depth (20), whereupon the cleaving action provides an expanding cleave front to free the donor material from a remaining portion of the donor substrate.

Abstract: A multi-level cell copyback program method in a non-volatile memory device is disclosed. The method includes reading LSB data of a source page, and storing the read LSB data in a second register of a page buffer, transmitting the data stored in the second register to a first register coupled to a data inputting circuit, and storing the transmitted data in the first register, amending the data stored in the first register through the data inputting circuit, transmitting the amended data to the second register, and storing the transmitted data in the second register, and LSB-programming corresponding data to a target page in accordance with the data stored in the second register.

Abstract: A page buffer circuit of a memory device including a plurality of Multi-Level Cells (MLCs) connected to at least a pair of bit lines includes a Most Significant Bit (MSB) latch, a Least Significant Bit (LSB) latch, a data I/O circuit, an inverted output circuit, a MSB verification circuit, and a LSB verification circuit. The MSB latch is configured to sense a voltage of a sensing node in response to a control signal and store an upper sensing data, and output an inverted upper sensing data, or store an input data and output an inverted input data. The LSB latch is configured to sense a voltage of the sensing node in response to the control signal, and store and output a lower sensing data, or store and output an input data received through the MSB latch. The data I/O circuit is connected to the MSB latch and a data I/O line, and is configured to perform the input and output of a sensing data or the input and output of a program data.

Abstract: A leadframe strip production process provides encapsulated semiconductor chips with more than two annular rows of exposed leads by utilizing two types of frames, a leadframe to which IC devices are mounted, and a ring frame strip that is attached to the leadframe with a non-conductive adhesive. The leadframe includes die pads that receive the IC chip devices, and each die pad is positioned within multiple rows of connecting pads for connection with bonding pads of the device to be encapsulated. The connecting pads of the leadframe are arranged in an annular fashion, with inner rows being closer to the die pad and outer rows being farther from the die pad.

Abstract: According to the invention, a method of making an eave for a roof on a building is disclosed. The method may include providing a structure with at least two sides and a roof frame. The method may further include coupling at least two of a plurality of eave blocks with a first trim piece. The method may also include coupling at least two of the plurality of eave blocks with a second trim piece. The method may further include coupling a roof piece with a top of the roof frame and a top of at least two of the plurality of eave blocks. In some embodiments, the eave blocks may include lumber having a grain direction and the method may include coupling the eave blocks with the first trim piece such that the grain direction is substantially parallel to a length of the first trim piece.

Abstract: A network switching apparatus, a server system and a server migration method for the server system are provided which can perform server migration easily. The server system has a physical server, a physical server having a server virtualization mechanism, a network switching apparatus having a plurality of ports and a management server connected to the network switching apparatus for managing a server migration process for using a migration destination virtual server as the physical server of a migration source, wherein the management server has a migration mechanism for transmitting setting information to be designated to the plurality of ports to the network switching apparatus during the server migration process, and the network switching apparatus changes settings of the plurality of ports in accordance with the transmitted setting information on the plurality of ports.

Abstract: The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.

Abstract: A method for paying for an auction item at least partially using an online payment system by a payor to compensate a payee includes receiving at a host computer system payment information relating to a transaction. The payment information includes comprising at least a payee identifier, a first payment amount, and an auction identifier. The auction identifier relates to an auction that was won by the payor that was for the auction item. The method also includes generating a transaction identifier at the host computer system and transmitting the transaction identifier to the payor. The method further includes receiving at a retail location a payment and using the transaction identifier to relate the payment to the transaction. The method further includes making a second payment amount available to the payee. The second payment amount may be based on the payment.

Abstract: The present invention provides peptides comprising the amino acid sequence of SEQ ID NO: 8, 67, 89, as well as peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing tumors comprising these peptides. The peptides of the present invention can also be used as vaccines.

Abstract: A bit line of a semiconductor device includes a first interlayer dielectric film disposed on a semiconductor substrate, a plurality of bit line stacks disposed on the first interlayer dielectric film, a plurality of bit line spacers disposed on side walls of the bit line stacks, and a buffer film disposed on the bit line spacers, the first interlayer dielectric film and the bit line stacks; and a method for fabricating the same.

Abstract: The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

Abstract: A system includes an optical system having two beam splitters (a dichroic beam splitter and a polarizing beam splitter), which are designed to provide three separate beam paths for observing an object. The dichroic beam splitter is designed to separate two beam paths depending on the wavelength of the light of the respective beam path. The polarizing beam splitter is designed such that two beam paths are separated depending on a direction of polarization of the light of the respective beam path. The measuring light is linearly polarized after having passed the polarizing beam splitter and may be influenced with respect to the state of polarization by a retarding plate. The returning measuring light incident on the polarizing beam splitter is linearly polarized and also polarized in such a direction that the returning measuring light is transported through the polarizing beam splitter towards the analyzing detector with a high efficiency.

Abstract: The present invention provides exemplary bill paying service methods and systems. One such bill paying service method (1000) includes enrolling a subscriber (Step 1010) who is a debtor to a first creditor and who has authorized debits to be taken from a designated account. The designated account is adapted to periodically receive a payroll deposit on a first regular schedule that is over time in excess of a minimum payment on a first debt owed by the debtor to the first creditor. The designated account is periodically debited, and any funds obtained are used to credit a custody account (Step 1012). The first creditor is paid (Step 1016), on behalf of the debtor and from the custody account, on a second regular schedule that differs from the first regular schedule. Paying the first creditor occurs in an amount calculated for an accelerated repayment of the first debt (Step 1014).

Abstract: Provided are a power device package, which can be made compact by mounting semiconductor chips in recesses formed in a substrate and improve operational reliability by rapidly dissipating heat generated during operation to the outside, and a method of fabricating the power device package.

Abstract: A process for introducing microorganisms to carbonaceous material in an anaerobic environment is described. The process includes the step of extracting formation water from a geologic formation, and removing at least a portion of an extractable material from the formation water to make amended formation water. The process may further include introducing the amended formation water to the carbonaceous material. Also, a process for increasing biogenic hydrocarbon production in a geologic formation containing a carbonaceous material is described. The process includes extracting formation water from the formation, removing at least a portion of one or more hydrocarbons from the formation water to make amended formation water, and reintroducing the amended formation water to the geologic formation.

Abstract: Apparatus for bone reinforcement, fixation and treatment of diseased or fractured bones including a supporting structure optionally coated with therapeutic agent is provided. The supporting structure or device may be collapsible upon deployment at the surgical site, and include fixation features such as anchors to securely position in place once deployed. Bone cement or other material may be provided to alternatively secure the positioned supporting structure for treatment. A lockable bone fixation device is described that comprises: a sleeve adapted to be positioned in a space formed in a bone; a guidewire adapted to guide movement of the sleeve; and an actuable lock adapted to secure the sleeve within the space of the bone from an end of the device.

Abstract: The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.