Abstract: Techniques for generating a paper document that integrates notes written by a user and different types of captured or recorded information. A user can take written notes during an information communication event. While taking the notes, the user can identify, from information captured during the information communication event, information that is of interest to the user and that the user would like to integrate with or incorporate into the user's notes. A paper document is generated by printing a visual representation of the notes written by the user and the visual representations of portions of information that a user would like to integrate with the user's notes.
Abstract: Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices employed in the method of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These methods are useful in drug development, functional proteomics studies and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
Type:
Grant
Filed:
May 12, 2000
Date of Patent:
January 27, 2004
Assignee:
Zyomyx, Inc.
Inventors:
Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
Abstract: A method for forming a chamber or nozzle structure in a substrate. The chamber is formed by first creating a surface feature, such as a pit or trench, on the surface of the substrate. A layer of resist is applied to the sidewall of the surface feature and the substrate is isotropically etched such that the etch works back up the inside of the resist on the surface feature sidewall to form a re-entrant angle between the surface feature sidewall and the top of the chamber wall. This results in a chamber that is wider than the opening between the sidewalls of the surface feature. An anisotropic etch step may be performed before or after the isotropic etch step or steps to control the final shape of the chamber.
Abstract: A method and apparatus for coupling a tubular handle (4, 6) of an exercise device to a flexible line (10), such as an elastic cord, is described. The elastic flexible line is directed through a circumferential opening (60) in the handle and attached to the inner lumen of the handle with a coupling assembly (24). The coupling assembly comprises a retainer (30) defining a hole (40) for receiving the end portion of the flexible line and fastener (32) for securing the end portion of the flexible line to the retainer to thereby fix the line to the handle. The coupling assembly provides a strong mechanical link between the flexible elastic line and the handle that minimizes wear on the elastic line.