Patents Represented by Attorney, Agent or Law Firm Traci H. Ropp
  • ErbB4 antagonists
    Patent number: 7704498
    Abstract: The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: April 27, 2010
    Assignee: Genentech, Inc.
    Inventors: Mary E. Gerritsen, Mark X. Sliwkowski
  • Methods and composition for modulating and detecting wisp activity
    Patent number: 7456262
    Abstract: Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD44 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.
    Type: Grant
    Filed: June 28, 2003
    Date of Patent: November 25, 2008
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Ellen Filvaroff
  • Methods and compositions for modulating and detecting WISP activity
    Patent number: 7455834
    Abstract: Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: November 25, 2008
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyer, Ellen Filvaroff
  • Haemophilus adherence and penetration proteins
    Patent number: 6815182
    Abstract: Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: November 9, 2004
    Assignees: Washington, University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Joseph W St. Geme, III, Stanley Falkow
  • Methods of isolating the androgenic sex hormone from crustacean prawn and marine shrimp and methods of use
    Patent number: 6740794
    Abstract: This work constitutes a novel approach and methodology, e.g., the in vitro secretion method to isolate the androgenic polypeptide hormone (AH) from the androgenic gland of shrimp or prawns. Alternatively, the AH can be obtained recombinantly by cloning and expressing the AH gene. The AH polypeptide is used to produce phenotypic males, neomales, from genotypic female shrimp or prawns. The neomales find use in the production of sex-skewed and monosex offspring when mated with wild-type female shrimp or prawns. From the sequence of the purified AH polypeptide, oligonucleotide probes are synthesized to clone the AH encoding nucleic acid which is used for recombinant AH polypeptide expression.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: May 25, 2004
    Assignee: University of Hawaii
    Inventors: Spencer R. Malecha, Piera S. Sun
  • Cephalotaxine alkaloid compositions and uses thereof
    Patent number: 6734178
    Abstract: A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a cephalotaxine and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the cephalotaxine comprises homoharringtonine (cephalotaxine, 4-methyl-2-hydroxy-2-(4-hydroxy-4-methyl pentyl) butanediocate ester). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: May 11, 2004
    Assignee: ChemGenex Therapeutics, Inc.
    Inventor: Dennis M. Brown
  • Haemophilus adherence and penetration proteins
    Patent number: 6676948
    Abstract: Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: January 13, 2004
    Assignee: Washington University
    Inventor: Joseph W. St. Geme, III