Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Type:
Grant
Filed:
December 8, 2006
Date of Patent:
October 20, 2009
Assignee:
Rigel Pharmaceuticals, Inc.
Inventors:
Todd M. Kinsella, Esteban Masuda, Mark K. Bennett, Justin E. Warner, David C. Anderson