Abstract: The present invention provides systems and methods for controlling the speed of flap retraction on aircraft, and alerts to the pilot of potentially unsafe flap position. The invention accepts direction from a pilot and senses operation of the aircraft to determine appropriate flap position and flap retraction speed.

Abstract: The present invention provides methods and apparatuses that reduce pilot workload and increase the performance and efficiency of the pilot's control of the aircraft. The present invention comprises methods and apparatuses for determining the presence and type of an emergency condition, for example by detecting corresponding sensor outputs or by accepting input from a pilot or a combination thereof; and then responding to that emergency by initiating a pre-determined set of actions specific to the determined emergency. Embodiments of the invention can include the ability to monitor engine conditions as well as control electrical functions such as the fuel boost pump, alternator field, battery contactor and other important electrical devices. Some examples described below assume a single-engine piston aircraft for ease of illustration. The invention can also be applied to multi engine and turbine powered aircraft as well.

Abstract: Example embodiments of the present invention provide methods and apparatuses that enable the detection of bubbles so that hemodynamic performance can be assured following an automated blood analyte measurement. An example apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the blood back into the body. The infusion of at least a portion of the blood back in to the body can be done in a manner to assure that no bubbles of clinical significance are injected into the patient. Additionally an example embodiment can assess for the presence of bubbles in the fluid column that can affect hemodynamic monitoring performance. If a condition exists where hemodynamic monitoring performance cannot be assured, an example embodiment can provide appropriate warning or corrective actions.

Abstract: The present invention comprises methods and apparatuses that can provide reliable communications between a computer and a haptic interface device. The methods and apparatuses can provide communication that is more secure against errors, failures, or tampering than previous approaches. Haptic devices allow a user to communicate with computer applications using the user's sense of touch, for example by applying and sensing forces with the haptic device. The host computer must be able to communicate with the haptic device in a robust and safe manner. The present invention includes a novel method of accomplishing such communication; a computer-readable medium that, when applied to a computer, causes the computer to communicate according to such a method; and a computer system having a host computer and a haptic device communicating according to such a method.

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise measuring the fluorescence lifetime in either time-domain or frequency domain modes. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. For example, multivariate models can be developed that relate lifetime trends of one or more constituents to increasing propensity to diabetes and pre-diabetes.

Abstract: An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Abstract: Embodiments of the present invention provide an apparatus with a flexible probe suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to a flexible optical probe. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light.

Abstract: Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe can be a flexible probe in some embodiments, allowing ease of application. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof.

Abstract: The present invention includes an ophthalmic device and system of mounting for correcting hyperopia and presbyopia. The present invention includes a limbus ring mountable in an encircling relation to a central optic zone of a cornea on a limbus annulus surrounding the cornea. In the limbus ring defines a substantially annular toroid defining a first average diameter that is selectable and has a hydrophilic coating disposed thereon. The inner radius of the limbus ring is selectable such that, upon mounting on the limbus annulus, the limbus ring causes the limbus annulus to contract thereby causing the curvature of the cornea and the eye length to increase. The mounting system of the present invention is adapted to receive a limbus ring and further adapted to selectively place the limbus ring on a limbus annulus.

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue.

Abstract: A computer-implemented function monitors and displays exhaust gas temperatures (EGT) in a plurality of cylinders in an engine. The invention provides an easy way to read exhaust gas temperature on a specific cylinder, and to provide a means for leaning the engine while in a climb. Efficient leaning in a climb reduces fuel consumption and reduces the chance of harmful conditions that can lead to engine failure.

Abstract: The invention relates to methods and devices for the decontamination of fluid, particularly the removal of heavy metals and/or arsenic and/or their compounds from water, by means of electrolysis, wherein the water to be purified subjected to electrodes of different polarities. The invention can include means for control of the pH of the fluid. The invention can also include control systems that allow self-cleaning of electrodes, self-cleaning of filters, and automatic monitoring of maintenance conditions.

Abstract: The present invention relates generally to non-invasive methods and apparatuses for determining analyte properties of a subject and identity characteristics of a subject. Embodiments of the present invention provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely that in systems that include separate analyte and identity determinations. The invention can be used to prevent operation of automobiles or other equipment unless the operator has an acceptable alcohol concentration, and to limit operation of automobiles or other equipment to authorized individuals who are not intoxicated or drug-impaired.

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue.

Abstract: SQUID imaging of a subject's head after the subject having been administered superparamagnetic nanoparticles comprising: an iron-containing core, a coating covering the core and a probe molecule conjugated to the coating wherein the probe molecule locates the superparamagnetic nanoparticle to a target in the brain that is characteristic of the neurodegenerative disease; magnetizing the superparamagnetic nanoparticles using external magnetic coils; and measuring the decaying remanence magnetic fields of the superparamagnetic nanoparticles attached to the target and not from unattached superparamagnetic nanoparticles to obtain magnetic field measurements.

Abstract: A switching and fault detection circuit comprises two controllable switches capable of coupling a power source to a load. A controller can control the switches and test them for faults, and a voltage sensor can read the output voltage going to the load. Dual-redundant switches and fault detection circuitry can provide correct operation if one should fail. Control and feedback logic can determine if each of the solid-state switches is operating correctly during the power-on and power-off cycles and can also check for a fail-open condition during normal operations. If it is determined that a solid switch has failed open or closed, a fault can be generated.

Abstract: The present invention provides a human-computer interface. The interface includes provision of an application domain, for example corresponding to a three-dimensional application. The user is allowed to navigate and interact with the application domain. The interface also includes a personal domain, offering the user controls and interaction distinct from the application domain. The separation into two domains allows the most suitable interface methods in each: for example, three-dimensional navigation in the application domain, and two- or three-dimensional controls in the personal domain. Transitions between the application domain and the personal domain are under control of the user, and the transition method is substantially independent of the navigation in the application domain. For example, the user can fly through a three-dimensional application domain, and always move to the personal domain by moving a cursor near one extreme of the display.

Abstract: The present invention provides improved methods and apparatuses for accurate measurements using interferometers. A functional relationship between the optical path difference and time is determined from a reference signal from an interferometer. The times at which the interferometer had specific optical path differences can be determined from the functional relationship. Those times can then be used to select times at which the spectroscopic signal from the interferometer was produced at the specific optical path differences. The invention can be applied, as examples, to maintain instrument calibration, and to transfer or compare calibrations or measurements across different interferometers.

Abstract: A novel active contact lens system configured to allow the wearer to alter the corrective features of the contact lens by means of a biasing force. The biasing force can, for example, be different eye drop solutions having different pH levels.

Abstract: An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product. Methods of making such probes are described.