Patents Represented by Attorney, Agent or Law Firm Valeri J. Camara
  • Oxidation process using periodic acid
    Patent number: 6172231
    Abstract: The present invention relates to a periodic acid oxidation which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula I having a carboxylic acid.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: January 9, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Zhiguo Song, Mangzu Zhao, David M. Tschaen