Patents Represented by Attorney, Agent or Law Firm Valerie E. Looper
  • Patent number: 7910562
    Abstract: A molecular delivery complex specific to antigen-presenting cells is formed from a non-viral gene delivery system complexed with foreign genetic material. The complex then enters the targeted cells through a specific receptor and overcomes the degradation mechanism, so that functional uptake of the foreign genetic material, or transduction, of the cell, results in gene expression. The invention also includes a method for genetic immunization without a needle.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: March 22, 2011
    Assignee: Genetic Immunity, LLC
    Inventors: Julianna Lisziewicz, Franco Lori
  • Patent number: 7205283
    Abstract: New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: April 17, 2007
    Assignee: Rexahn Corporation
    Inventors: Heejeong Yoon, Lingjun Mao, Young Bok Lee, Chang-Ho Ahn, Xiaoming Jiang
  • Patent number: 7196186
    Abstract: A plasmid DNA that encodes one or more antigenic genes operably linked to a promoter and a truncated retroviral 3? LTR exhibits both enhanced safety and acceptable efficiency of expression of antigenic proteins.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: March 27, 2007
    Assignee: Research Institute for Genetic and Human Therapy (R.I.G.H.T.)
    Inventors: Julianna Lisziewicz, Jianqing Xu, Franco Lori
  • Patent number: 7122527
    Abstract: New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: October 17, 2006
    Assignee: Rexahn Corporation
    Inventors: Heejeong Yoon, Lingjun Mao, Young Bok Lee, Chang Ho Ahn
  • Patent number: 7088059
    Abstract: A control circuit for a lighting system allows analog control over a first range of illumination intensities in which the intensity of the illumination source varies in proportion to the voltage level of the control signal. The circuit provides for improved dimming and color mixing capability by allowing pulse width or frequency modulation control in addition to analog control over a second range of illumination intensities.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: August 8, 2006
    Assignee: Boca Flasher
    Inventors: Steven J. McKinney, Matthew C. Polak
  • Patent number: 6420176
    Abstract: A molecular delivery complex specific to antigen-presenting cells is formed from a a non-viral gene delivery system complexed with foreign genetic material. The complex then enters the targeted cells through a specific receptor and overcomes the degradation mechanism, so that functional uptake of the foreign genetic material, or transduction, of the cell, results in gene expression. The invention also includes a method for genetic immunization without a needle.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: July 16, 2002
    Assignee: Genetic Immunity, LLC.
    Inventors: Julianna Lisziewicz, Franco Lori
  • Patent number: 6251874
    Abstract: A method for treating HIV infection in human beings comprising the step of measuring viremia, and if viremia is less than 50,000-100,00 copies per milliliter, administering a combination of compounds selected from the group consisting of hydroxyurea, and one or more reverse transcriptase inhibitors.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: June 26, 2001
    Assignee: Research Institute for Genetic and Human Therapy (R.I.G.H.T.)
    Inventors: Julianna Lisziewicz, Franco Lori
  • Patent number: 6130089
    Abstract: The subject invention provides methods for improving the efficiency of gene transfer to a target cell. The methods are particularly advantageous in that they facilitate the transduction of quiescent cells. In a preferred embodiment the efficiency of gene transfer using a viral vector is enhanced by transiently loading the dytosol of the target cell with dNTP and by transiently adding viral receptors to the surface of the target cell.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: October 10, 2000
    Inventor: Julianna Lisziewicz
  • Patent number: 6114312
    Abstract: A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a combination of compounds selected from the group consisting of hydroxyurea, a nucleoside analog, and a protease inhibitor.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: September 5, 2000
    Assignee: Research Institute for Genetic and Human Therapy (R.I.G.H.T.)
    Inventors: Julianna Lisziewicz, Franco Lori
  • Patent number: 6083386
    Abstract: A method for treating waste from animal husbandry sites. The process is a closed loop system with no need for an anerobic lagoon.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: July 4, 2000
    Assignee: AgTech Environmental, Inc.
    Inventor: Paul Don Lloyd
  • Patent number: 6045857
    Abstract: Unsaturated hydrophobic resins modified with labile hydrophillic groups exhibit reversible solubility in water. Beta-dialkyl amino carboxylate derivatives of novolak resins are useful to make baking enamels and resists.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: April 4, 2000
    Assignee: MacDermid Acumen, Inc.
    Inventor: Goutam Gupta
  • Patent number: 5977086
    Abstract: A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a combination of compounds selected from the group consisting of hydroxyurea, a nucleoside analog, and a protease inhibitor.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: November 2, 1999
    Assignee: R.I.G.H.T.
    Inventors: Julianna Lisziewicz, Franco Lori
  • Patent number: 5804393
    Abstract: The present invention relates to an antibody which reacts specifically with the binding proteins for Bacillus thuringiensis .delta.-endotoxins and their derivatives. The invention further relates to an anti-idiotype antibody which reacts specifically with the binding proteins for Bacillus thuringiensis .delta.-endotoxins and their derivatives. The invention also provides a test kit which contains a novel antibody. The invention further relates to a method of isolating a novel B. thuringiensis .delta.-endotoxin, to said novel B. thuringiensis .delta.-endotoxin, to a method of identifying a novel B. thuringiensis .delta.-endotoxin which recognises a novel binding protein, to the novel B. thuringiensis .delta.-endotoxin, to a method of determining the amount of binding protein present, and to a method of reducing the resistance development potential in pest control.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 8, 1998
    Assignee: Thermo Trilogy Corporation
    Inventors: Martin Geiser, Pascale Oddou Stock, Herbert Hartman
  • Patent number: 5681684
    Abstract: To provide a water-developable photosensitive resin composition capable of forming a resist film that excels in hardness, heat resistance and water resistance.The photosensitive resin composition of this invention is characterized by containing an unsaturated epoxy ester compound which is obtained by reacting the remaining epoxy side group of a partially carboxylic acid-esterified unsaturated epoxy ester compound with an aliphatic tertiary amine in the presence of an alcoholic solvent to convert it into a quaternary ammonium salt.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: October 28, 1997
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Keiichi Kinashi, Reiko Chiba
  • Patent number: 5583047
    Abstract: A method of detecting the permeability of an article to oxygen is disclosed. A fluorescent redox indicator, preferably riboflavin, is dispersed in a carrier and placed on an impermeable substrate. The article to be measured is placed adjacent to the carrier. Residual oxygen is removed, the redox indicator is photoreduced, the article and carrier are exposed to oxygen, and the indicator is exposed to UV light.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: December 10, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Thomas A. Blinka, Christopher Bull, Charles R. Barmore, Drew V. Speer
  • Patent number: 5567792
    Abstract: A curing agent for epoxy resins is prepared from an amine and an epoxy, as well as subsequent modification by a polyisocyanate compound, in such a manner that the curing agent is in the form of small spherical particles. The particles can be as small as 0.1 microns. This curing agent can be easily dispersed in curing agent masterbatches and curable compositions with minimal effect on their storage stability. The resulting curable compositions have a wide range of applications, including automobile and electronic adhesives.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 22, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Souichi Muroi, Hsi-Chuan Tsai
  • Patent number: 5561204
    Abstract: A curing agent for epoxy resins is prepared from an amine and an epoxy, as well as subsequent modification by a polyisocyanate compound, in such a manner that the curing agent is in the form of small spherical particles. The particles can be as small as 0.1 microns. This curing agent can be easily dispersed in curing agent masterbatches and curable compositions with minimal effect on their storage stability. The resulting curable compositions have a wide range of applications, including automobile and electronic adhesives.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 1, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Souichi Muroi, Hsi-Chuan Tsai
  • Patent number: 5554714
    Abstract: A curing agent for epoxy resins is prepared from an amine and an epoxy, as well as subsequent modification by a polyisocyanate compound, in such a manner that the curing agent is in the form of small spherical particles. The particles can be as small as 0.1 microns. This curing agent can be easily dispersed in curing agent masterbatches and curable compositions with minimal effect on their storage stability. The resulting curable compositions have a wide range of applications, including automobile and electronic adhesives.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 10, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Souichi Muroi, Hsi-Chuan Tsai
  • Patent number: 5548058
    Abstract: A curing agent for epoxy resins is prepared from an amine and an epoxy, as well as subsequent modification by a polyisocyanate compound, in such a manner that the curing agent is in the form of small spherical particles. The particles can be as small as 0.1 microns. This curing agent can be easily dispersed in curing agent masterbatches and curable compositions with minimal effect on their storage stability. The resulting curable compositions have a wide range of applications, including automobile and electronic adhesives.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 20, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Souichi Muroi, Hsi-Chuan Tsai
  • Patent number: 5529833
    Abstract: Products and film structures using the oxygen scavengers, are disclosed. Such products demonstrate enhanced shelf stability of foodstuffs and reduced sensitivity to humidity and temperature changes.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: June 25, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Drew V. Speer, Charles R. Morgan, William P. Roberts, Andrew W. VanPutte