Patents Represented by Attorney Valerie Fedowich

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  • Preparation of optically active spiro-hydantoins
    Patent number: 5206367
    Abstract: This invention relates to the preparation of preparing optically-active asymmetric spiro-hydantoin compounds, which are known to be of value in the medical control of certain chronic diabetic complications arising from diabetes mellitus. This invention also includes within its scope certain corresponding novel amino and hydantoic acid compounds and the cinchonine salt of optically active hydantoic acid, which are used as intermediates in the aforesaid process.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: April 27, 1993
    Assignee: Pfizer Inc.
    Inventor: Frank J. Urban
  • Preparation of diazabicyclic Intermediates
    Patent number: 5196548
    Abstract: Diazabicyclo[2.2.1]heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C.sub.1 -C.sub.6)alkyl-5-substituted-2,5-diazabicyclo[2.2.1]heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic quinolones.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: March 23, 1993
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox