Patents Represented by Attorney, Agent or Law Firm Valerie J. Camera
  • 11-hydroxysordarin and a process for producing it using actinomyces SSP
    Patent number: 6228622
    Abstract: 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: May 8, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Michel M. Chartrain, Guy H. Harris, Jennifer Nielsen-Kahn, Brian Heimbuch
  • Process for the crystalization of losartan
    Patent number: 5859258
    Abstract: Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure. ##STR1## This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: January 12, 1999
    Assignee: Merck & Company, Inc.
    Inventors: Patrick Breen, Erik A. Dienemann, Albert D. Epstein, Karen A. Larson, Michael T. Kennedy, Hari Mahadevan
  • Stereoselective process
    Patent number: 5708186
    Abstract: This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the .alpha.-halo acid with an aryloxy group.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: January 13, 1998
    Inventors: Paul N. Devine, David M. Tschaen, Richard M. Heid, Jr.