Patents Represented by Attorney Vicki H. Audia

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  • Hydroxy-amino acid amides
    Patent number: 5892038
    Abstract: Compounds of Formula I ##STR1## are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: April 6, 1999
    Assignee: Pharmacopeia, Inc.
    Inventors: Roland Ellwood Dolle, III, Hitesh K. Patel
  • Method and apparatus for generating and representing combinatorial chemistry libraries
    Patent number: 5880972
    Abstract: A method and apparatus is provided for the generation and representation of chemical libraries. More particularly, a computer-implemented method and apparatus is provided for the generation and representation of combinatorial chemistry libraries.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: March 9, 1999
    Assignee: Pharmacopeia, Inc.
    Inventor: Eric G. Horlbeck
  • Hydroxy-amino acid amides
    Patent number: 5872262
    Abstract: Compounds of Formula I ##STR1## are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: February 16, 1999
    Assignee: Pharmacopeia, Inc.
    Inventors: Roland Ellwood Dolle, III, Hitesh K. Patel, Theodore O. Johnson, Jr., Carolyn DiIanni Carroll, Shiwei Tao