Patents Represented by Attorney, Agent or Law Firm Vince Liptak
  • Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
    Patent number: 6750024
    Abstract: The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: June 15, 2004
    Assignee: Applera Corporation
    Inventors: Linda G. Lee, Ronald J. Graham, Khairuzzaman B. Mullah, Francis T. Haxo