Abstract: PKC modulating compounds of the formula ##STR1## Also disclosed are pharmaceutical compositions including these compounds which inhibit PKC activity, methods of using these compounds to inhibit PKC activity in mammals, and intermediates useful in preparing the PKC modulating compounds.

Abstract: Disclosed are oligonucleotide compounds that inhibit interleukin receptor expression when administered to a human subject. Also disclosed are pharmaceutical compositions and methods for inhibiting human interleukin receptor expression.

Abstract: In a method for the production of a sealing and adhesive strip, particularly for the direct glazing of motor vheicles, using a moisture-hardening single-component polyurethane composition based on telechelic isocyanate prepolymers of aromatic diisocyanates in stoichiometric excess and polyols a composition is employed comprising a) a catalyst for the moisture-hardening and b) a blocked activatable cross-linking agent, and a solvent or solvent mixture is continually injected into the inside of the strip during the extrusion of the strip which liberate the cross-linking agent.For the implementation of the method an extrusion nozzle for the sealing and adhesive strip is used which comprises an injection needle for the solvent opening into the nozzle, the exit opening of which points in the extrusion direction and is located in the region of the center axis of the extrusion die forming the strip.

Abstract: The present invention relates to a method of treating an inflammatory condition, and to compounds and composition suitable for use in such a method, which compounds have the Formula: ##STR1## wherein: X is methylene, ethylene, ethyleneoxy, or oxygen;Q is ##STR2## where C' is a residue of a lipophilic amino acid, and Y is --CO.sub.2 H, --CH.sub.2 OH, --CONR.sub.1 R.sub.2, or --CO.sub.2 R.sub.1 where R.sub.1 and R.sub.2 hydrogen, alkyl, or aryl;R.sub.3 and R.sub.4 are, independently, hydrogen, alkyl or aryl; andA and B are, independently, hydrogen, fused phenyl, alkyl, aryl, alkaryl, aralkyl, alkoxy, alkoxyalkyl, halogen, or nitro;or pharmaceutically acceptable salts thereof.

Abstract: For the at least partial curing of sealants and adhesives in particular in connection with the direct glazing of motor vehicles, at least part of the sealant and adhesive is heated by applying microwave energy.

Abstract: The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexia nervosa, cardiovascular abnormalities and stress-induced immune suppression. The invention also relates to compounds (4-substituted thio-5-oxo-3-pyrazolines) and to pharmaceutical compositions suitable for use in such a method.

Abstract: The invention pertains to a method and pharmaceutical compositions for treating, preventing or reducing neurodegeneration associated with chronic central nervous system or hypoxic, ischemic and hypoglycemic injury to the central nervous system and for the treatment of anxiety through the use of 2-amino-.omega.-phosphonoalkanoic acids having a cycloalkyl group bridging adjacent carbons on the alkyl chain, their pharmaceutically acceptable salts and derivatives as neuroprotectants and anxiolytics.

Abstract: A novel class of polyimides useful in making semipermeable membranes for gas separation is synthesized by the reaction of 4,4'-[hexafluoroisopropylidene]-bis-[phthalic anhydride] (6FDA) with 3,7-diamino-2,8-dimethyldiphenylenesulfone (AMPS). In lieu of the two methyl groups the diamine may be substituted by H or C.sub.2-4 alkyl. Membranes made from the polyimides have high permeability for CO.sub.2 from mixtures containing CO.sub.2 and other gases such as CH.sub.4 and have commercially acceptable selectivity.

Abstract: A waterproofing system including a water-based latex primer composition and a waterproofing adhesive membrane. The primer exhibits excellent adhesion to concrete and an excellent surface for adhesion by the waterproofing membrane. The primer is a latex emulsion including butyl acrylate, styrene and acrylonitrile.

Abstract: Process and apparatus for separation of hydrogen, methane, and higher hydrocarbons from gas feed stock. For example, such feedstock is fed to a gas-liquid separator, the resulting gas is treated in a gas-gas membrane separator, the residue is separated in a second gas-liquid separator, and the permeate is separated in a second gas-gas membrane separator; the process may be repeated until the desired effluent specificity is achieved.

Abstract: Disclosed are semipermeable fluid separation membranes prepared from polyaromatic polymers including aromatic repeat units of which at least five mole percent are substituted by moieties having ethylenically unsaturated carbon bonds wherein the polymer is crosslinked through carbon bonds between the ethylenically unsaturated moieties. The invented membranes have enhanced durability yet retain very high fluid, especially gas, permeability.

Abstract: An improved method is disclosed for coupling membrane elements of a fluid separation module in series. The improvement comprises providing flexible coupling members having two open ends and a passage between said ends; and securing the first end of a coupling member to the residual end of each membrane element (with the optional exception of the last in the series) and securing the second end of the coupling member to the feed end of the next membrane element in the series if any. Fluid from the residual end of each membrane element except the last may thus be directed to the feed end of the next membrane element. An improved fluid separation module employing such couplings is disclosed; as is an improved membrane element having a coupling member secured thereto.

Abstract: A liquid, solvent-free or low solvent hardenable polyurethane-modified bitumen composition is described, which is based on a bitumen modified with a polyurethane prepolymer. The compatability between bitumen and polyurethane prepolymer is achieved by a plasticizer system comprising a primary and a secondary plasticizer. The inventive composition is particularly suitable as an adhesive, sealant, foam material or coating compound.

Abstract: In a process for bonding two substantially flat elements, a highly viscous sealant containing balls as spacers is applied to a first element in a thickness at least corresponding to the desired distance from the second element and the latter is engaged and pressed onto the first element. The balls (6) are successively added to the sealant in an applicator nozzle (2) prior to the application of the sealant. This process can be performed with an apparatus having an applicator nozzle (2) for the supply and application of the sealant (4) and a ball supply device (10). The latter contains a supply duct (12) for supplying the balls (6), an outlet tube (14) connected at an angle to supply duct (12) and issues via an opening (16) laterally into the applicator nozzle (2) and an impact plunger (18), which is movable by the end remote from applicator nozzle (2) into the outlet tube (14).

Abstract: An improved method for using a membrane to separate gases provides for relieving the pressure on the permeate side of the membrane when the permeate pressure exceeds the feed pressure by a selected amount. Gas separation apparatus in general and, in particular, spiral wound membrane units are improved by providing for relief of such reversed pressure differentials. A suitable device for relieving the reversed pressure differential includes a body, a poppet movably mounted to the body and biased to a closed position until the selected pressure differential is reached, and a seal for preventing gas flow through the device when the poppet is closed.

Abstract: A two-component material based on curable prepolymers and conventional additives is described which, unlike conventional two-component materials, contains hardenable prepolymer in both individual components, the prepolymer in the first component being a polyurethane prepolymer with free NCO-groups and the prepolymer in the second component is a polymer with free SH-groups. The first component contains curing agent and optionally accelerator for the polymer with free SH-groups and the second component contains curing agent and optionally accelerator for the polyurethane prepolymer with free NCO-groups. Through the use of two prepolymers, the two components of the two-component material can be used in a volume ratio favorable for practical purposes. It is also possible to set the viscosity and density of the two individual components to roughly the same values, so that no problems are caused when mixing the two components.

Abstract: A liquid, solvent-free or low-solvent hardenable polyurethane-modified bitumen composition is described, which is based on a bitumen modified with a polyurethane prepolymer. The compatibility between bitumen and polyurethane prepolymer is achieved by a plasticizer system comprising a primary and a secondary plasticizer. The inventive composition is particularly suitable as an adhesive, sealant, foam material or coating compound.

Abstract: New intermediates, namely 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines, are prepared by a synthetic sequence which uses a Darzen's reaction in a homogeneous solvent system.

Abstract: Potent DBH Inhibitors having the formula: ##STR1## wherein R is --CO.sub.2 H or --CH.sub.2 NHR.sup.1 can be used to inhibit DBH activity in mammals.

Abstract: 2,3,4,8,9,9a-Hexahydro-4-aryl-1H-indeno[1,7-cd;]-azepines are selective dopamine receptor site binding agents.