Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
Type:
Grant
Filed:
August 21, 1992
Date of Patent:
September 18, 2001
Assignees:
Scripps Research Institute, Medical Research Council, Stratagene
Inventors:
Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
Type:
Grant
Filed:
September 4, 1992
Date of Patent:
September 18, 2001
Assignees:
Scripps Research Institute, Medical Research Council, Stratagene
Inventors:
Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
Type:
Grant
Filed:
August 21, 1992
Date of Patent:
September 18, 2001
Assignees:
Scripps Research Institute, Medical Research Council, Stratagene
Inventors:
Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
Abstract: The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular advantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 4, 2001
Assignee:
Large Scale Biology Corporation
Inventors:
Jon Donson, William O. Dawson, George L. Grantham, Thomas H. Turpen, Ann M. Turpen, Stephen J. Garger, Laurence K. Grill
Abstract: A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly produced proteins from plant hosts thereby making the large scale use of plants as sources for recombinant protein production feasible.
Type:
Grant
Filed:
February 9, 2000
Date of Patent:
September 4, 2001
Assignee:
Large Scale Biology Corporation
Inventors:
Thomas H. Turpen, Stephen J. Garger, Michael J. McCulloch, Terri I. Cameron, Michelle L. Samonek-Potter, R. Barry Holtz
Abstract: The invention provides a method for increasing hydration and lubrication of lacrimal tissues in a subject in need of such treatment. The method comprises administering to the subject a nicotinic acetylcholine receptor agonist such as nicotine and its analogs, transmetanicotine and its analogs, epibatidine and it analogs, lobeline and its analogs, pyridol derivatives, para-alkylthiophenol derivatives, and imidacloprid and its analogs, in an amount effective to stimulate mucus secretion in the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the formulation include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation, suppository form, or transdermal form.
Abstract: The present invention relates to a hypertonia gene located on chromosome 12p in the genomic region between genome markers AFM338WH5 and D12S1057 and uses of such a gene.
Type:
Grant
Filed:
February 5, 1999
Date of Patent:
June 19, 2001
Assignee:
Progen Biotechnik GmbH
Inventors:
Nihat Bilginturan, Sylvia Bähring, Friedrich Luft, Herbert Schuster, Thomas Wienker
Abstract: The present invention relates to a transduction system, comprising (a) a rep-negative AAV vector containing a foreign DNA and (b) a product providing an AAV Rep protein. The invention also relates to the use of the transduction system.
Type:
Grant
Filed:
May 5, 1999
Date of Patent:
March 27, 2001
Assignee:
Medigene AG
Inventors:
Gerd Maass, Christoph Bogedain, Michael Hallek, Clemens Wendtner, Doris Michl
Abstract: This invention relates to potentiating insulin activity in a patient in need thereof. This invention provides a composition comprising an insulin potentiating agent; such composition comprises one or more substance derived from a water extract of Polygonum multiflorum, Agaricaceae, or Cinnamomum mairei. This invention also provides a method for treating hyperglycemia in a patient by administering to the patient an insulin potentiating agent. The method can be used to decrease blood glucose and/or glycosylated hemoglobin and/or glucose level.
Abstract: The present invention relates to an expression system for anaerobic gene expression in higher plants. The expression system comprises the promoter GapC4 or a fragment or variant and a gene to be expressed. A concrete field of application of the present invention is agriculture, particularly resistance cultivation.
Type:
Grant
Filed:
October 27, 1998
Date of Patent:
February 27, 2001
Assignee:
MPG Cologne GmbH Molecular Plant & Protein
Biotechnology
Inventors:
Rüdiger Cerff, Klaus Düring, Reinhard Hehl, Uwe Köhler
Abstract: The present invention provides methods and compositions for inhibiting microbial growth through the use of aromatic aldehydes or alcohols for the purpose of disinfecting contaminated environments. The methods include the step of contacting the unsterile area with an amount of a aromatic aldehyde or alcohol sufficient to control growth of pathogenic microbes. The aldehyde or alcohol can be provided in a variety of formulations.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
December 1, 1998
Assignee:
Proguard, Inc.
Inventors:
Ralph W. Emerson, Bradford G. Crandall, Jr.
Abstract: Methods and compositions based upon natural aromatic compounds are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitos, lice, ants, cockroaches, lice, and ticks.
Type:
Grant
Filed:
March 25, 1996
Date of Patent:
November 24, 1998
Assignee:
Proguard, Inc.
Inventors:
Ralph W. Emerson, Bradford G. Crandall, Jr.
Abstract: Repellent compositions which contain aromatic aldehydes such as cinnamic aldehyde, .alpha.-hexyl cinnamic aldehyde and/or coniferyl aldehyde are provided, together with methods for their use as repellents for pests including flies, cockroaches, aphids, silverleaf white flies, mosquitoes, ticks, fleas, lice, leafhoppers, thrips, two-spotted spider mites, snails, slugs, biting midges, earwigs, and moths. Also provided are stabilized .alpha.-hexylcinnamic aldehyde (HCA) compositions which reduce the evaporation rate of HCA and/or induce HCA to evaporate at a constant rate over time.
Type:
Grant
Filed:
December 24, 1996
Date of Patent:
August 11, 1998
Assignee:
Proguard, Inc.
Inventors:
Ralph W. Emerson, Bradford G. Crandall, Jr.
Abstract: The present invention provides methods and compositions for inhibiting microbial growth through the use of flavonoid aldehydes or alcohols for the purpose of disinfecting contaminated environments. The methods include the step of contacting the unsterile area with an amount of a flavonoid aldehyde or alcohol sufficient to control growth of pathogenic microbes. The aldehyde or alcohol can be provided in a variety of formulations.
Type:
Grant
Filed:
November 22, 1995
Date of Patent:
April 14, 1998
Assignee:
Proguard, Inc.
Inventors:
Ralph W. Emerson, Bradford G. Crandall, Jr.