Abstract: Polymer compositions and processes consisting of mixture of vinyl chloride polymer and polyether urethane with tertiary amine and/or ammonium groups and heparin. The compositions can be converted into shaped articles, e.g. tubes, cannulae, catheters and the like useful in the medical field.

Abstract: Polymers formed by incomplete esterification of the hydroxy groups of a water-soluble polymer such as polyvinyl alcohol, amylose or dextran with a pharmacologically acceptable mono- or di-carboxylic acid to an extent sufficient to render the polymer water-insoluble although still water-swellable, are biodegradable. They are useful for the formulation of pharmaceutical compositions for parenteral administration, particularly in the form of injectable fine particles in which a drug is intimately mixed with or encapsulated by the polymer.

Abstract: Polymer compositions of a mixture of vinyl chloride polymer and polyurethane with tertiary amine and/or ammonium groups and heparin.

Abstract: The present invention relates to mass transfer apparatus e.g., artificial kidney in which a semipermeable membrane is folded or pleated between top and bottom rectangular plates. Support members are disposed within each pleat on one side only of the membrane. The top and bottom plates are held under a predetermined compressive load while a connecting means with ports is bonded to the opposite side edges of the top and bottom plates. The whole pleated membrane assembly is secured within a housing, with the ports protruding through the housing. The apparatus has reproducible performance characteristics from one device to another.

Abstract: The invention concerns a hollow fibre separatory device. The opened ends of the hollow fibres are situated in a plane which is at an acute angle relative to the axes of end sections of the fibres. A reservoir is provided which defines a fluid flow passage leading across the open ends of the fibres from a region adjacent the acute angle at the periphery of the plane to the opposing peripheral region. Fibre end openings are signficantly larger than the normal open cross-sectional area.Also disclosed are processes for producing the hollow fibre separatory devices. Including in particular a novel procedure for introducing solidifiable sealing material at an acute angle relative to the ends of hollow fibres.

Abstract: The invention provides solid enteric-coated compositions in unit dose form for oral application, the core of the composition containing an ergot alkaloid and a polyalkoxyalkylene sterol ether. The compositions are characterized by a prolonged effect and a good bioavailability of the active agent. The core may be in solid solution form. The enteric-coating may also be surrounded by an outer medicament layer.

Abstract: This invention provides an apparatus and process for automatically coating solid pharmaceutical dosage forms, e.g., tablets. The apparatus comprises a coating pan, having a rotating means, e.g., motor and a weighing means, e.g., scales in combination with the pan and motor. A process controller is in electronic communication with both the pan motor and scales, for controlling the pan rotation and monitoring the weight of the coating pan contents. There is also provided a plurality of material containing reservoirs having conduit means communicating with the interior of the pan. The material containing reservoirs may also have weighing means, e.g., scales in combination with the reservoirs, which are also in electronic communication with the process controller. These reservoirs may contain a water supply, a coating syrup supply, color suspension supply, and polishing ingredients for use in coating the tablets.

Abstract: Polymer compositions comprising a mixture of vinyl chloride polymer and polyetherurethane with tertiary amine and/or ammonium groups. The compositions can be converted into shaped articles, e.g. tubes, cannulae, catheters and the like useful in the medical field.

Abstract: A process for preparing polymers compositions of a mixture of vinyl chloride polymer and polyurethane with tertiary amine and/or ammonium groups.

Abstract: The present invention provides a pharmaceutical composition comprising a pharmacologically active monocyclic peptide and a carrier comprising at least one of the following components:(a) a non-ionic ester of a triglyceride and a polyalkylene polyol,(b) a saturated fatty acid triglyceride, and(c) a mono- or di-glyceridehaving improved physical and absorption properties.

Abstract: Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.

Abstract: Fluid treatment apparatus is disclosed in which a stack of flat membrane elements and support plates are enclosed and compressed by means of a casing which comprises two endplates between which the stack is arranged, the internal faces of the endplates being adapted to contact the faces of the stack which is substantially parallel to the plane of the elements, and at least two lateral plates are located with their internal surfaces in front of the lateral faces of the stack. A number of studs and cooperating recesses are provided in adajcent surfaces of each lateral plate and each endplate, whereby the lateral plates and endplates are connected together within cooperating engagement surfaces, which are disclosed as being cylindrical, of its stud and recesses, hold the endplates and lateral plates together and thus hold the stack compressed.

Abstract: This invention provides a compression process for the production of suppositories characterized in that the compression step is effected at a temperature at or below +10.degree. C., and in the absence of a binding agent.

Abstract: A liposome medicament delivery system wherein the medicament is encapsulated in a liposome comprising an aliphatic liquid-sterol-water lamellae. The lipid may be a sodium or potassium salt of a C.sub.4 to C.sub.18 fatty acid, and the sterol may be cholesterol.

Abstract: An improved cutting system for knitted fabrics, wherein a cutting element is mounted on a knitting machine for movement in unison with the needle and positioned to cut the knitted fabric to a predetermined dimension at least one cycle after the knitting cycle.

Abstract: A method of making a plurality of bundles of hollow fibres with potted ends in which a plurality of channels are mounted, one or each side of the periphery of a polygonal wheel, with the open side of each channel facing radially outwardly. A hollow fibre, or a hank of hollow fibres, are fed to the wheel, which is rotated so that the fibres engage in the channels, and build up therein to form a bundle in each channel.Glue is applied by causing the fibre or fibres to engage intermittently on a glueing roller located upstream of the wheel, so that the glue is located at spaced intervals only on the fibre or fibres corresponding to the locations at which potting is required. The fibres are cut adjacent the point where the glue is applied.The channels may form part of the final hollow fibre apparatus, in which case the glue will be allowed to adhere to the channels also.

Abstract: Method and apparatus are disclosed for controlling dialysis and ultrafiltration. Precision control over the operation of an artificial kidney (dialyzer), particularly the removal of waste water by ultrafiltration, is achieved by the use of two pumps in the respective paths to and from the artificial kidney. One of the pumps may be operated at constant speed and the other at a variable speed under control from a level sensor at the storage tank, whereby a prescribed rate of ultrafiltration is maintained by a third pump. If desired, the pumps may be operated at complementary speeds so that as the speed of one is increased, the speed of the other is decreased, maintaining a prescribed rate of ultrafiltration by a third pump, under the control of the level sensors at the tank. A further feature provides automatic switching back and forth between two storage tanks of blood cleansing fluid (dialysate) in conjunction with the two pumps in the respective paths to and from the artificial kidney.