Abstract: Substantially pure compositions of matter selected from the group of cephalostatin 7, cephalostatin 8, and cephalostatin 9 having anti-neoplastic activity are disclosed.
Type:
Grant
Filed:
January 19, 1993
Date of Patent:
December 10, 1996
Assignee:
Arizona Board of Regents acting on behalf of Arizona State University
Abstract: Pancratistatin has been selected for pre-clinical development but is sparingly soluble in water. A disodium phosphate derivative has been synthesized which is water soluble and is bioequivalent thereof. The critical step in the synthesis of the phenolic phosphate was phosphorylation of 1,2,3,4-tetraacetoxy-pancratistatin with dibenzyloxy(N,N-diisopropylamido)phosphine.
Type:
Grant
Filed:
January 9, 1995
Date of Patent:
June 25, 1996
Assignee:
Arizona Board of Regents acting on behalf of Arizona State University
Abstract: The isolation, elucidation and synthetic replication of novel pentapeptide mides and esters are described. The compounds have the general structure ##STR1## in which R.sub.1 and R.sub.2 are selected as shown below: ##STR2##R.sub.1 =CH.sub.3 ; R.sub.2 =--O--CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 16a)R.sub.1 =CH.sub.3 ; R.sub.2 =--O--CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 16b)R.sub.1 =CH.sub.3 ; R.sub.2 =--NH--CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.
Type:
Grant
Filed:
August 1, 1994
Date of Patent:
May 28, 1996
Assignee:
Arizona Board of Regents acting on behalf of Arizona State University
Abstract: The Micronesian marine sponge Phakellia sp. has been found to contain cern key members of the antineoplastic halichondrin/halistatin family. These compounds include halichondrin B, homohalichondrin B, halistatin 1, and halistatin 3.Halistatin 3 is a newly discovered member of this family. It inhibited both the P388 leukemia cell line and selected brain, lung, colon, ovarian, renal, and melanoma type cancer cell lines with ED.sub.50 /GI.sub.50 concentrations on the order of 3.times.10.sup.-5 .mu.g/ml.
Type:
Grant
Filed:
April 7, 1995
Date of Patent:
May 21, 1996
Assignee:
Arizona Board of Regents acting on behalf of Arizona State University
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