Abstract: Anti-CD4 antibody homologs, DNA sequences and recombinant DNA molecules encoding them, prophylactic, immunotherapeutic and diagnostic compositions comprising those antibody homologs, and methods for preventing or treating diseases in mammals, including humans, caused by infective agents whose primary targets are CD4.sup.+ lymphocytes. Such diseases include acquired immune deficiency syndrome ("AIDS"), AIDS related complex, and human immunodeficiency virus infection.
Type:
Grant
Filed:
November 27, 1991
Date of Patent:
February 16, 1999
Assignee:
Biogen, Inc.
Inventors:
Linda C. Burkly, Patricia L. Chisholm, David W. Thomas, Margaret D. Rosa, Joseph J. Rosa