Patents Represented by Attorney Warren D. McPhee
  • Patent number: 4127607
    Abstract: Process for preparing di-n-propyl acetamide of the formula: ##STR1## whereby di-n-propyl acetonitrile is hydrolyzed by means of 80% sulphuric acid aqueous solution in the proportion of 2 to 2.5 g of dilute acid/g of nitrile, at a temperature between 80.degree. C and 130.degree. C to obtain the desired amide.
    Type: Grant
    Filed: May 25, 1977
    Date of Patent: November 28, 1978
    Assignee: Labaz
    Inventors: Michel Chignac, Claude Grain, Charles Pigerol
  • Patent number: 4127604
    Abstract: Process for the preparation of di-n-propyl acetic acid of formula: ##STR1## and its non-toxic alkali and alkaline earth metal salts whereby in a single stage, sodium n-propylate in n-propanol medium is added to a reaction medium formed of a cyanacetic ester of general formula: ##STR2## in which R represents an alkyl radical having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium or potassium hydroxide, the salt thus obtained is acidified with a strong acid, to give the crude di-n-propyl cyanacetic acid, which is decarboxylated by heating at a temperature between 140.degree. and 190.degree. C, to provide the di-n-propyl acetonitrile, the di-n-propyl acetonitrile obtained is hydrolysed by means of an aqueous solution of 75 to 80% sulphuric acid at a temperature of 80.degree.-140.degree.
    Type: Grant
    Filed: May 25, 1977
    Date of Patent: November 28, 1978
    Assignee: Labaz
    Inventors: Michel Chignac, Claude Grain, Charles Pigerol
  • Patent number: 4127609
    Abstract: Cyclohexanediol derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which are identical, each represent a N.sub.3 or NH.sub.2 group, and the acid addition salts of the derivative containing two NH.sub.2 groups.These compounds are useful as intermediate products for the preparation, for example, of synthetic antibiotics.
    Type: Grant
    Filed: January 22, 1976
    Date of Patent: November 28, 1978
    Assignee: Labaz
    Inventors: Andre Cier, Stephan Gero, Alain Olesker, Jean Leboul
  • Patent number: 4124710
    Abstract: The invention relates to acetamidoxime derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 represents a branched- or straight-chain alkyl group containing from 1 to 4 carbon atoms or a phenyl group, A represents one of the groups: ##STR2## R.sub.2 represents an amino group such as, for example, a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, pyrrolidino, morpholino, piperidino or heptamethyleneimino group or a 1-piperazino group substituted in the 4-position by a straight-chain alkyl group containing from 1 to 4 carbon atoms, X represents a hydrogen or chlorine atom or a methoxy group and n is the integer 2 or 3.The compounds of formula I have been found to be potentially useful in the treatment of disorders of arterial pressure.
    Type: Grant
    Filed: December 9, 1976
    Date of Patent: November 7, 1978
    Assignee: Labaz
    Inventors: Marcel Descamps, Alex Areschka