Patents Represented by Attorney, Agent or Law Firm Warren D. Woessner
  • Patent number: 6339087
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: January 15, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Patent number: 6323223
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: November 27, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Patent number: 5733915
    Abstract: A therapeutic method for the treatment of Crohn's disease is provided, comprising administering to a patient in need of said treatment an intravenous dose of azathioprine or a pharmaceutically acceptable derivative thereof.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: March 31, 1998
    Assignee: Glaxo Wellcome Inc.
    Inventor: William J. Sandborn
  • Patent number: 5384253
    Abstract: The present invention provides a method to increase the susceptibility of cultured Zea mays cells to stable transformation with recombinant DNA via electroporation, by pretreating the Zea mays cells with certain pectin-degrading enzymes, so that the cells retain their ability to regenerate fertile, transgenic Zea mays plants containing the DNA which is also heritable.
    Type: Grant
    Filed: December 28, 1990
    Date of Patent: January 24, 1995
    Assignee: DeKalb Genetics Corporation
    Inventors: Richard A. Krzyzek, Cheryl R. M. Laursen, Paul C. Anderson
  • Patent number: 5352680
    Abstract: A motion provided to alleviate the tolerance to, or dependence on, an opiate analgesic, by the administration of an effective amount of a selective delta opioid receptor antagonist to a human patient in need of such treatment.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: October 4, 1994
    Assignee: Regents of the University of Minnesota
    Inventors: Philip S. Portoghese, Akira E. Takemori
  • Patent number: 5352771
    Abstract: The present invention provides a method for the selective cleavage of peptide amide bonds under ambient conditions by treating a peptide comprising the subunit --CO--NH--CH((CH.sub.2).sub.x SY)CONH-- wherein x is 1-2 and Y is H or (C.sub.1 -C.sub.4)alkyl in an aqueous medium with a tetracoordinate Pd(II) or tetracoordinate Pt(II) complex which promotes the hydrolysis of the adjacent amide bond proximal to the carboxy terminus of the subunit.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: October 4, 1994
    Assignee: Iowa State University Research Foundation Inc.
    Inventors: Nenad M. Kostic, Longgen Zhu
  • Patent number: 5346619
    Abstract: Carbon-clad zirconium oxide particles are disclosed which are useful in sorbent applications, particularly as packing materials for High Performance Liquid Chromatography (HPLC). A method for the preparation of chromatographic support material is also disclosed which utilizes low pressure.
    Type: Grant
    Filed: July 14, 1993
    Date of Patent: September 13, 1994
    Assignee: Regents of the University of Minnesota
    Inventors: Eric F. Funkenbusch, Peter W. Carr, Douglas A. Hanggi, Thomas P. Weber
  • Patent number: 5316907
    Abstract: A method of measuring adenylate cyclase (AC) in a sample of physiological material which does not employ radioactive reagents is provided, comprising:(a) providing a physiological sample of physiological material comprising cAMP produced by endogenous AC, and other endogenous adenine nucleotides selected from the group consisting of ATP, AMP, ADP and mixtures thereof;(b) combining the sample with effective amounts of apyrase, 5'-nucleotidase and adenosine deaminase, so as to enzymatically eliminate the other endogenous adenine nucleotides in the sample;(c) enzymatically converting the cAMP into AMP; and(d) measuring the amount of AMP, the amount providing a measure of the amount of cAMP and AC in the sample.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: May 31, 1994
    Assignee: Regents of the University of Minnesota
    Inventors: Keith G. Lurie, Phi Wiegn
  • Patent number: 5314727
    Abstract: A method is provided for forming films comprising Fe, Ru or Os employing the techniques of chemical vapor deposition to decompose a vapor comprising an organometallic compound of the formula (a): (CO).sub.4 ML or (b): M.sub.2 [.mu.-.eta.:.eta..sup.4 -C.sub.4 ](CO).sub.6 ; wherein L is a two-electron donor ligand and each R is H, halo, OH, alkyl, perfluoroalkyl or aryl; so as to deposit a coating comprising one or more of said metals on the surface of a substrate.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: May 24, 1994
    Assignee: Minnesota Mining & Mfg. Co./Regents of the University of Minnesota
    Inventors: Fred B. McCormick, Wayne L. Gladfelter, Yoshihide Senzaki
  • Patent number: 5312527
    Abstract: The present invention relates to a voltammetric sequence-selective sensor for target polynucleotide sequences which essentially comprises: an immobilized polynucleotide probe having one end covalently bound onto an amperometric electrode. The immobilized probe includes a target binding region capable of hybridizing to the target polynucleotide sequences forming an immobilized heteroduplex having at least a hybridized region. The sequence-selective sensor of the present invention also comprises means for voltammetrically detecting immobilized heteroduplexes. There is also provided a method for detecting the presence of a target polynucleotide analyte in a physiological sample, which comprises the steps of incubating the prepared physiological sample with the voltammetric sequence-selective sensor of the present invention; voltammetrically detecting immobilized heteroduplexes; and comparing the resulting voltammogram with a control voltammogram.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: May 17, 1994
    Assignee: Concordia University
    Inventors: Susan R. Mikkelsen, Kelly M. Millan, Aleksandrs J. Spurmanis
  • Patent number: 5306727
    Abstract: Cyclophosphamide analogs are provided of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are each (C.sub.2 -C.sub.6)alkyl, substituted with a leaving group such as halo or alkylsulfonyl, R.sup.3 and R.sup.4 are the same as R.sup.1 and R.sup.2 or are H and Ar is a heteroaromatic ring and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: April 26, 1994
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Richard F. Borch, James P. Schmidt
  • Patent number: RE34594
    Abstract: Corn gluten meal is used as a natural preemergence herbicide.
    Type: Grant
    Filed: October 1, 1992
    Date of Patent: April 26, 1994
    Assignee: Iowa State University of Research Foundation, Inc.
    Inventor: Nick E. Christians