Abstract: A self-contained wireless interactive speech recognition control device and system that integrates with automated systems and appliances to provide totally hands-free speech control capabilities for a given space. Preferably, each device comprises a programmable microcontroller having embedded speech recognition and audio output capabilities, a microphone, a speaker and a wireless communication system through which a plurality of devices can communicate with each other and with one or more system controllers or automated mechanisms. The device may be enclosed in a stand-alone housing or within a standard electrical wall box. Several devices may be installed in close proximity to one another to ensure hands-free coverage throughout the space. When two or more devices are triggered simultaneously by the same speech command, real time coordination ensures that only one device will respond to the command.

Abstract: A method for preparing a volume of blood for cellular analysis in a hematology instrument includes the step of gently mixing the blood sample with a reagent and/or diluent using a stream of air. Preferably, the air stream is directed at the liquid(s) to be mixed at a relatively steep angle, preferably less than about 10 degrees from the normal to the liquid surface. A mixing vessel adapted for use in a hematology instrument for carrying out the method of the invention comprises a cap that supports an air jet for directing the air stream at an angle in keeping with the method of the invention.

Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.

Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.

Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.

Abstract: Method and apparatus for controlling the temperature of one or more reaction vessels in a bio-chemical analyzer comprises a heat-exchange block, preferably made of cast aluminum or the like, and a thermoelectric device for heating or cooling the block to within a desired temperature range. The heat-transfer block cradles one or more reaction vessels in a thermal energy-transferring relationship, and further supports, in a thermal energy-transferring relationship, one or more fluid conduits serving to transmit a liquid or gas to the interior of the reaction vessels. Preferably, the heat-transfer block is cast from aluminum, and the fluid conduits are disposed inside the casting.

Abstract: Apparatus for aspirating and dispensing liquid samples in an analytical instrument, e.g., a hematology instrument, includes a liquid-sampling valve that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has been aspirated into the valve by a pump, simultaneously enables the apparatus to be operated in an aspirate/dispense (suck-and-spit) mode in which a liquid sample can be selectively driven through the valve in opposite directions by a pump, e.g., a syringe pump.

Abstract: Apparatus for aspirating liquid from a container, e.g., a test tube, having a puncturable stopper includes a pair of stepper motors that share a common linear actuator or drive member. One motor operates to axially advance the linear drive member (preferably a lead screw) to a position in which it serves to position a rigidly connected tube-detector/stripper member in engagement with the top of a stopper on a tube. Thereafter, the second motor operates to move along the surface of the same drive member to advance an aspiration probe through the engaged stopper and into a liquid aspirating position within the tube. Preferably, a linear guide rail, slidably-mounted on a frame that supports the liquid-aspirating apparatus, serves to guide both the movement of the aspiration probe and the linear drive member. As a result of the shared components, the apparatus is highly precise and reliable.

Abstract: A method and apparatus for selectively sorting individual particles, such as blood cells of a particular type of interest, from a plurality of particles of different types. Particles of interest are individually differentiated from other particles in a known manner, and a discrete control signal is produced in response to having identified a particle of interest. An impulse generator, acting in response to such control signal, applies a focused impulsive force on the identified particle of interest, such force serving to eject such particle from the plurality of particles of which it is a part. The ejected particles of interested are then collected in a separate container. The apparatus of the invention is preferably embodied in a flow cytometric instrument.

Abstract: A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such sample preparation can be eliminated, leading to a process that readily lends itself to automation and the advantages associated therewith. The method of the invention comprises the steps of (a) cell-fixation, (b) permeabilization and (c) staining (or labeling) of intracellular molecules of interest by probes that are readily detectable by flow cytometric techniques, all without any intervening cell-washing (and re-suspension) steps. Rather, the single cell-washing step is effected after these three steps have been carried out. Preferably, the washing step is carried out by passing the fixed, permeabilized and stained cell sample through a semi-permeable membrane that serves to filter out (by transmission) interferants to waste while retaining the cells of interest.

Abstract: A magnetically-attractive specimen-container rack for use with a magnetic transport system for transporting racks of specimen-containers to or within an automated clinical instrument for analysis and/or processing. The specimen-container rack comprises a pair of U-shaped magnetically-attractive members mounted in the base section of the rack housing so that the distal ends of such members extend towards the base of the rack and terminate in a plane slightly short of the plane in which the rack is supported for movement atop a rack-supporting surface. Such members are adapted to cooperate with similarly-shaped permanent magnets carried by an X/Y-movable truck that underlies a non-magnetic rack-supporting plate.

Abstract: A method and apparatus for controlling the processing of a liquid sample, e.g., a blood sample, based on a measurement related to the sample's ability to coat a surface against which the sample is brought into contact while being routinely transported. Preferably, the sample is advanced through a tube, and the amount of sample residue remaining within the tube is measured and correlated to coating process subsequently carried out on the sample, e.g., a process for producing blood-smears on a microscope slide. In a preferred embodiment, the amount of sample residue in a blood-transport tube is used to control the motion profile (i.e., acceleration and velocity) of a drop-spreading member used to spread a blood drop on a microscope slide in an automated slide-making instrument.

Abstract: Apparatus and method for aspirating liquid from a container, e.g., a test tube or other vessel, includes apparatus for sensing that an aspiration probe tip is contacting the inside bottom wall of the container, whereby a maximum volume of liquid can be aspirated from the container. According to the invention, an encoder is mounted on the driven member of a motor (e.g., on a rotatably-driven drive shaft or a nut of a stepper or D.C. motor, or on a linearly-driven shaft of a linear actuator) used to rectilinearly advance the probe tip into the container. Such encoder produces a series of pulses indicating the speed and/or linear position of the probe tip. A motor controller responds to a predetermined change in pattern of pulses from the encoder indicating that movement of the probe tip has been resisted by the vessel bottom, whereby further movement of the driven member and of the probe connected thereto is arrested, and the probe tip remains in contact with the vessel bottom.

Abstract: A method and apparatus for sensing different levels of liquids in their respective containers in a liquid-consuming and/or producing instrument system. According to a preferred embodiment, an elongated liquid-sensing probe having axially spaced electrodes adapted to sense liquid at multiple levels is arranged in each container of liquid. A controller, e.g. a suitably programmed microprocessor, operates to selectively poll different pairs of electrodes carried by the probe to determine whether or not the polled electrode pairs are immersed in the contained liquid. Preferably, the polling circuit comprises an electronically-controlled resistor that serves to normalize the level-sensing output signal for liquids of different bulk resistivity.

Abstract: A magnetic specimen-transport system for transporting racks of specimen-containers to or within an automated clinical instrument for analysis and/or processing. The magnetic specimen-transport system that is adapted to transport magnetically-attractable racks of specimen-containers in mutually perpendicular (X/Y) directions across a rack-supporting surface, whereby the racks can be transported among various non-linearly aligned positions on such surface.

Abstract: A snow-gun for producing man-made snow from a combination of compressed air and water features a new nozzle configuration for discharging a mixture of water-particles and air into the surrounding atmosphere. Such nozzle is provided with an elliptically-shaped discharge port having a transverse cross-section that gradually expands in size in the direction in which the air and water particles are discharged from said nozzle. Preferably, the area of the elliptical port changes non-linearly through the front wall of the nozzle, whereby water particles exiting the gun through the nozzle port are less likely to collide with the side walls of the port or with each other before reaching the relatively cold ambient atmosphere.

Abstract: An apparatus and method for directly determining the hemoglobin content (CH) of individual sphered red blood cells and for directly determining the width of the cell hemoglobin distribution of a red blood cell sample. Such apparatus and method monitors the light reflected by individual sphered cells as they are made to pass through an optical flow cell while being irradiated by a suitable source of radiation.

Abstract: A method and apparatus for detecting back-scattered light from small particles, such as blood cells, irradiated by a focused beam of light as such particles travel through the interrogation zone of a standard optical flow cell in a flow cytometer. Back-scattered light is collected at a location upstream of the beam-shaping optics (or a portion of such optics), at a location between the light beam source and the beam-shaping optics.

Abstract: A magnetic specimen-transport system for transporting racks of specimen-containers to or within an automated clinical instrument for analysis and/or processing. The magnetic specimen-transport system that is adapted to transport magnetically-attractable racks of specimen-containers in mutually perpendicular (X/Y) directions across a rack-supporting surface, whereby the racks can be transported among various non-linearly aligned positions on such surface.

Abstract: Apparatus for detecting light scattered by a small particle (e.g., a blood cell) irradiated by a light beam comprises one or more photodetectors and a plurality of optical fibers that serve to optically couple the scattered light and the photodetector(s). To enhance the efficiency of such optical coupling, a portion of each of the optical fibers in the vicinity of its light-collecting end is supported so that its optical axis extends towards the light-scattering source. By this arrangement, scattered light enters each fiber from a direction substantially parallel to the fiber axis. Preferably, the light-collecting ends of the optical fibers are supported on a concave surface and so that the respective optical axes of the fibers converge at a point representing the apparent position of the light-scattering source, taking into account the refractive effects of an optical flow cell through which scattering is detected.