Abstract: There is disclosed a method for treating advanced cancer in patients in need of such treating. Temozolomide and cisplatin are administered in combination in amounts sufficient to achieve a clinical response.

Abstract: A dispenser for dispensing metered amounts of a viscous material includes a rigid tube which defines a compartment for the material, a discharge passage at one end of the tube, a push button activated and reciprocatingly movable rod which moves back and forth between two positions in the tube, and a sealing plunger which moves step-wise on the rod, from the push button end to the discharge end. Each activation of the push button expels a metered amount of the viscous material. The plunger is formed of a short inner tube section which makes sealing contact with the rod, an outer tube section which is in sealing contact with the interior surface of the tube and a radially extending, ring-shaped, rib which connects the two sealing tubes to one another. In a preferred embodiment, the radial cross-section of the plunger exhibits and H-shape. A metallic gripper is secured to the plunger and has a free end which is inclined toward the rod.

Abstract: A method for making a cosmetic pencil having a lead of solvent-based cosmetic composition.The leads are packaged in an airtight container, such as a plastic bag and stored in a freezer at a temperature below approximately 0.degree. for approximately 12 to 168 hours. The leads are then stored at room temperature for at least two hours and unpackaged. Then the leads are encased in grooved slats to form an assembly which is wrapped with airtight wrapping.