Abstract: An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines.
Abstract: Embodiments of the present invention are directed to method and devices for measuring the pressure of a pump chamber in which no internal opening or connections are needed. One embodiment of the present invention is directed to an apparatus for pumping fluid. The apparatus comprises at least one housing having a transducer surface. The transducer surface has a thickness exhibiting measurable deformation upon the chamber holding a fluid under pressure such that the transducer surface has a first position at which the chamber is at one pressure and a second position at which the chamber is at a second pressure. A strain sensor is affixed to the transducer surface producing; at least one signal upon the transducer surface assuming the first position and at least one signal upon the transducer surface assuming the second position to function as an integrated pressure transducer.
Type:
Grant
Filed:
March 4, 2005
Date of Patent:
December 18, 2012
Assignee:
Waters Technologies Corporation
Inventors:
Joseph A. Luongo, John Angelosanto, Frank Rubino, Stanley P. Pensak, Jr., David J. First, Jean-Pierre Pugnaire, Richard R. Venable
Abstract: A method for making a fluid-processing apparatus involves mixing a colloidal suspension with a matrix material, applying the mixture to a surface of a conduit, and curing the applied mixture to provide a conductive coating. A fluid-processing apparatus includes a conduit and a conductive layer adjacent to a surface of the conduit. The conductive layer includes graphite particles embedded in a matrix. The fluid-processing apparatus supports, for example, electrospray-ionization for mass spectrometry, capillary electrophoresis, or capillary electro-chromatography.
Type:
Grant
Filed:
May 24, 2006
Date of Patent:
October 30, 2012
Assignee:
Waters Technologies Corporation
Inventors:
Ananya Dubey, Jeffrey W. Finch, Jennifer H. Granger, James P. Murphy
Abstract: A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.
Type:
Grant
Filed:
July 1, 2005
Date of Patent:
November 22, 2011
Assignee:
Micromass UK Limited
Inventors:
Jose M. Castro-Perez, Alan Millar, Robert S. Plumb
Abstract: An Electrospray ionization ion source is disclosed comprising a capillary tube surrounded by a gas nebulizer tube. One or more wires are provided within the capillary tube. An analyte solution is supplied to the capillary tube and a nebulizing gas is supplied to the gas nebuliser tube.
Abstract: A mass spectrometer and method of mass spectrometry are disclosed wherein two separate samples are mass analysed and then the relative intensity, concentration or expression level of one or more components, molecules or analytes in a first sample is quantitated relative to the intensity, concentration or expression level of one or more components, molecules or analytes in a second sample. The relative quantitation is performed probabilistically without the need to resort to using internal calibrants.
Type:
Grant
Filed:
May 3, 2005
Date of Patent:
September 6, 2011
Assignee:
Micromass UK Limited
Inventors:
Richard Denny, Keith Richardson, John Skilling