Patents Represented by Attorney, Agent or Law Firm Wayne J. Dustman
  • Methods of treating hyperlipidemia with substituted azaspiranes
    Patent number: 5395848
    Abstract: This invention discloses a method of treating hyperlipidemia in a mammal by administering an effective amount of a substituted azaspirane.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: March 7, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter J. Bugelski, Wiliam D. Kerns
  • Method of treating prostatic adenocarcinoma
    Patent number: 5300294
    Abstract: Invented is a Method of Treating Prostatic Adenocarcinoma by employing a steroid 5-.alpha.-reductase inhibiting compound or a combination of steroid 5-.alpha.-reductase inhibiting compounds.
    Type: Grant
    Filed: June 27, 1990
    Date of Patent: April 5, 1994
    Assignee: SmithKline Beecham Corporation
    Inventor: Randall K. Johnson
  • Polystyrene anion exchange polymers
    Patent number: 5273740
    Abstract: Polystyrene polymers bearing a quaternary ammonium group are disclosed. They are useful in the treatment of hypercholesterolaemia and the prevention of atherosclerosis. A compound of the invention is 6-(N,N-dimethyl-N-octylammonio)hexanoylated polystyrene chloride.
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: December 28, 1993
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey, Virendra P. Shah
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 5237065
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: August 17, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Polystyrene anion exchange polymer pharmaceutical composition
    Patent number: 5230885
    Abstract: Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer, chloride salt.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: July 27, 1993
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey
  • Naphthyl-,tetrahydronaphthyl-, and indanyl-substituted G-em-diphosphonates and process of use to treat hyperlipidemia
    Patent number: 5204336
    Abstract: Substituted gem-diphosphonate compounds having use as cholesterol lowering agents are disclosed. A compound of the invention is tetraethyl-2-[3-t-butyl-4-hydroxynaphthyl]ethenylidene-1,1-diphosphonate.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: April 20, 1993
    Assignee: Symphar S.A.
    Inventors: Lawrence I. Kruse, Virendra P. Shah
  • Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
    Patent number: 5137882
    Abstract: Invented are 3-acetic acid-steroidal compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase including using these compounds to reduce prostate size and to treat prostatic adenocarcinoma. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: August 11, 1992
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Polystyrene anion exchange polymers
    Patent number: 5112922
    Abstract: Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N,N-dimethyl-N-(2-(N,N-dimethylcarbamoyl)ethyl)-ammoniomethyl-substitut ed polystyrene, chloride salt.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: May 12, 1992
    Assignee: Smith Kline & French Laboratories
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey
  • Intermediates in the preparation of steriod 5-alpha-reductase inhibitors
    Patent number: 5110939
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: May 5, 1992
    Assignee: Smithkline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Polystyrene anion exchange polymers
    Patent number: 5110875
    Abstract: Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N-(2-N,N-dimethylamino)ethyl)-N,N-dimethylammoniomethyl-substituted polystyrene, chloride salt.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: May 5, 1992
    Assignee: Smith Kline & Franch Laboratories Limited
    Inventors: Albert A. Jaxa-Chamiec, Deirdre M. B. Hickey
  • Crosslinked pyridinomethacrylate polymers
    Patent number: 5098701
    Abstract: Pyridiniomethacrylate polymers are described which are of use in the treatment of elevated serum cholesterol levels. A compound of the invention is cross-linked 3-(N-methyl-3-pyridinio)propyl methacrylate chloride.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: March 24, 1992
    Assignee: SmithKline & French Laboratories, Ltd.
    Inventors: Deirdre M. B. Hickey, David G. Cooper
  • 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-.alpha.-reductase
    Patent number: 5041433
    Abstract: Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: August 20, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Brian W. Metcalf, Mark A. Levy
  • 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
    Patent number: 5032586
    Abstract: Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are methods for preparing these compounds.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: July 16, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Brian W. Metcalf, Dennis A. Holt, Mark A. Levy
  • Phosphinic acid substituted steroids as inhibitors of steroid 5.alpha.-reductase
    Patent number: 5026882
    Abstract: The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: June 25, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of HMG-COA reductase
    Patent number: 5023250
    Abstract: New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: June 11, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Timothy F. Gallagher, Ruth J. Mayer, Brian W. Metcalf
  • Steriod 5-alpha-reductase inhibitors
    Patent number: 5017568
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: March 23, 1990
    Date of Patent: May 21, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Conrad J. Kowalski, Mark A. Levy, Brian W. Metcalf, Ann M. Tickner
  • Process for preparing substituted isoindolinone derivatives
    Patent number: 4997954
    Abstract: This invention relates to an improved process for the preparation of substituted indolinone derivatives using reductive cyclization conditions.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: March 5, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Joseph M. Fortunak
  • 3-substituted nitro-steroid derivatives as 5-.alpha.-reductase inhibitors
    Patent number: 4970204
    Abstract: Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: November 13, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase
    Patent number: 4970205
    Abstract: Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: November 13, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Aromatic steroid 5-.alpha.-reductase inhibitors
    Patent number: 4954446
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: September 4, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf