Patents Represented by Attorney Wayne R. Eberhardt
  • Patent number: 5358970
    Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: October 25, 1994
    Assignee: Burroughs Wellcome Co.
    Inventors: Michael D. Ruff, Sanyasi R. Kalidindi, Joel E. Sutton, Jr.
  • Patent number: 5182369
    Abstract: A method for purifying and recovering biologically active somatotropin monomers from refold solution following the solubilization and naturation of refractile bodies of host cells produced by recombinant DNA methodology. The purification process is based on the discovery that somatotropin monomers and somatotropin oligomers having overlapping isoelectric points may nevertheless be separated by selective precipitation over a narrow pH range. Host cell residues including proteins, pyrogens and other impurities present in the refold solution are effectively removed in the process. The purified somatotropin monomers recovered from solution after removing precipitated solids are suitable for parenteral application to target animals without further purification.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: January 26, 1993
    Assignee: Monsanto Company
    Inventors: Stephen B. Storrs, Jeffrey S. Schorey
  • Patent number: 5156851
    Abstract: Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering having a weight of from about 3 to 25 ug/mm.sup.2.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: October 20, 1992
    Assignee: Monsanto Company
    Inventors: Ernesto J. Castillo, Kenneth E. Eigenberg, Kanaiyalal R. Patel, Milton J. Sabacky
  • Patent number: 5141922
    Abstract: A method for preparing polypeptides in bacteria with an alanine rather than a methionine at the N-terminus. The DNA sequence expressed has an alanine codon immediately following from at least one methionine codon, and allows for the expression of polypeptides having the amino acid sequence essentially the same as such naturally occurring eucaryotic protein as various bovine and porcine somatotropin species. In another important embodiment, the invention provides a class of compositions comprising certain valine-containing somatropin species which increase milk production in lactating mammals to a significantly greater extent than otherwise-identical leucine somatotropin species.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: August 25, 1992
    Assignee: Monsanto Company
    Inventor: Gwen G. Krivi
  • Patent number: 5130299
    Abstract: The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Robert J. Collier, Michael F. McGrath
  • Patent number: 5130422
    Abstract: Variant somatotropins are described in which the asparagine located in the 95-101 region are replaced by glutamine which somatotropins exhibits enhanced stability.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Gwen G. Krivi, Michael R. Schlittler, Bernard N. Violand
  • Patent number: 5130300
    Abstract: The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
    Type: Grant
    Filed: March 14, 1990
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Robert J. Collier, Michael F. McGrath
  • Patent number: 5112620
    Abstract: A therapeutic ointment having wet adherent properties and particularly well suited for delivery of medicaments to mucosal surfaces includes a base material comprising from about 3 to 15% by weight of a water soluble salt of a copolymer of methyl vinyl ether and maleic acid or anhydride in a polyethylene glycol ointment. Formulations of the base material with triamcinolone acetonide and lidocaine are particularly efficacious in the treatment of recurrent aphthous ulcers.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: May 12, 1992
    Assignee: Mikkur, Inc.
    Inventors: Michael A. Repka, Thomas G. Gerding
  • Patent number: 5109117
    Abstract: A method for the solubilization and naturation of somatotropin from refractile bodies produced by r-DNA technology wherein the refractile bodies are dissolved in an aqueous solution comprising a chaotropic agent such as urea or guanidine hydrochloride and a soluble organic alcohol such as isopropanol or benzyl alcohol. The solubilized protein is exposed to mild oxidation for a time sufficient to allow the protein to form disulfide bonds and refold to its native conformation. The presence of the alcohol suppresses the formation of somatotropin dimers and aggregates and results in higher yields of the desirable monomeric form of the protein.
    Type: Grant
    Filed: June 26, 1990
    Date of Patent: April 28, 1992
    Assignee: Monsanto Company
    Inventor: Sa V. Ho
  • Patent number: 5091185
    Abstract: Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering 3 to 25 .mu.m PVA/mm.sup.2.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: February 25, 1992
    Assignee: Monsanto Company
    Inventors: Ernesto J. Castillo, Kenneth E. Eigenberg, Kanaiyalal R. Patel, Milton J. Sabacky
  • Patent number: 5089473
    Abstract: Variant forms of mammalian somatotropins, particularly bovine and porcine somatotropin, in which the asparagine located between positions 95-101 has been replaced by glutamine exhibit enhanced stability at high pH and at elevated temperatures while retaining bioactivity equivalent to the corresponding unmutated somatotropins, and are useful in the treatment of animals to enhance growth and/or milk production.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: February 18, 1992
    Assignee: Monsanto Company
    Inventors: Gwen G. Krivi, Michael R. Schlittler, Bernard N. Violand
  • Patent number: 5023323
    Abstract: A method for the solubilization and naturation of somatotropin from refractile bodies produced by r-DNA technology wherein the refractile bodies are dissolved in an aqueous solution comprising a chaotropic agent such as urea or guanidine hydrochloride and a soluble surfactant such as sodium dodecylsulfate. The solubilized protein is exposed to mild oxidation for a time sufficient to allow the protein to form disulfide bonds and refold to its native conformation. The presence of the surfactant suppresses the formation of somatotropin dimers and aggregates and results in higher yields of the desirable monomeric form of the protein.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: June 11, 1991
    Assignee: Monsanto Company
    Inventor: Sa V. Ho
  • Patent number: 4987266
    Abstract: A process is provided for producing nitrophenetole where nitrochlorobenzene is reacted in a cosolvent of a monohydric alcohol and N-alkylpyrrolidone with aqueous alkali metal hydroxide.
    Type: Grant
    Filed: December 29, 1989
    Date of Patent: January 22, 1991
    Assignee: Monsanto Company
    Inventors: Richard J. Day, Harry B. Harlow, Dennis C. Owsley
  • Patent number: 4985404
    Abstract: Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: January 15, 1991
    Assignee: Monsanto Company
    Inventor: James W. Mitchell
  • Patent number: 4788146
    Abstract: Liquid loaded pads useful as wound and burn dressings are prepared from pellicles of microbially-produced cellulose obtained, for example, by culturing Acetobacter xylinum. A pellicle having a thickness from about 0.1 to 15 millimeters or greater is processed to replace the culture medium with water or other physiologically compatible liquid. The liquid-loaded pellicle is sterilized prior to its use as a dressing or in other medical applications.
    Type: Grant
    Filed: January 9, 1986
    Date of Patent: November 29, 1988
    Assignee: Johnson & Johnson Patient Care, Inc.
    Inventors: David F. Ring, Wilson Nashed, Thurman Dow
  • Patent number: 4756882
    Abstract: A sterilization process wherein articles contacted with hydrogen peroxide and containing trace amounts of residual hydrogen peroxide are subjected to plasma treatment to generate an active species from the residual hydrogen peroxide which effects sterilization of the article and concurrently removes the residual hydrogen peroxide by converting it into non-toxic decomposition products.
    Type: Grant
    Filed: January 27, 1987
    Date of Patent: July 12, 1988
    Assignee: Surgikos Inc.
    Inventors: Paul T. Jacobs, Szu-Min Lin
  • Patent number: 4735842
    Abstract: A light weight entangled nonwoven fabric formed by fluid rearrangement/entangling of an oriented web of fibers comprising at least 75% polyolefin staple fibers and displaying excellent machine direction and cross direction strength.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: April 5, 1988
    Assignee: Chicopee
    Inventors: Conrad C. Buyofsky, John W. Kennette
  • Patent number: 4733794
    Abstract: A container comprising a tubular body members of rectangular cross-section and a hinged lid member having a skirt formed by shallow depending walls adapted to telescope closely over the walls of the body member when the lid is in the closed position, is provided with latching means and a projection on the outside of each side wall of the body member adjacent the open end thereof having an interference fit with the inside surface of the side wall of the lid member, whereby compressive forces are exerted by the lid member on the side walls of the body member as the lid is closed, thereby causing the front wall of the body member to flex slightly to assure the positive engagement of the latching means.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: March 29, 1988
    Assignee: Johnson & Johnson Products, Inc.
    Inventor: John R. Kent
  • Patent number: 4716234
    Abstract: Ultraviolet light absorbing compositions comprising 2-(2'-hydroxy-5'-acryloyloxyalkoxyphenyl(-2H-benzotrizoles, and copolymers thereof with one or more other monomers copolyermizable therewith, particularly acrylic monomers, are useful in the manufacture of ocular devices, particularly intraocular lenses and contact lenses.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: December 29, 1987
    Assignee: Iolab Corporation
    Inventors: Gary B. Dunks, Akira Yamada, Charles D. Beard, Namassivaya Doddi
  • Patent number: D293694
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: January 12, 1988
    Assignee: Johnson & Johnson Products, Inc.
    Inventors: Harry E. Alden, Thomas D. Policastro, Jr.