Abstract: The invention provides a composition for attenuating neovascularization and treating malignancies, including a pharmaceutically effective amount of a compound having a formula:
wherein:
R1 is a number of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy,
R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and
R3 is a member of the group consisting of hydrogen and lower alkenoxy carbonyl, as active ingredient therein, in combination with a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
January 10, 2000
Date of Patent:
July 16, 2002
Assignees:
Madasit Medical Research Services & Development Co.,
Ltd., Agricultural Research Organization-Ministry of
Agricultural
Inventors:
Mark Pines, Israel Vlodavsky, Arnon Nagler
Abstract: An inhibitor of adhesion formation which can be used to prevent adhesions within the abdominal cavity, particularly following surgical intervention, trauma or inflammation in the area is disclosed. Specifically, the most preferred compound of the present invention. Halofuginone, can be used to prevent collagen deposition from occurring within the peritoneum after surgical intervention, thereby inhibiting adhesion formation. Halofuginone, and related compounds, are useful in the prevention and treatment of both inflammatory and surgically induced adhesions, and in the treatment of congenital adhesions.
Type:
Grant
Filed:
December 8, 2000
Date of Patent:
September 3, 2002
Assignees:
Hadasit Medical Research Services & Development Co.,
Ltd., Agricultural Research Organization-Ministry of
Agriculture