Abstract: A high titer fermentation process using transformed Escherichia coli cells carrying a plasmid containing DNA which codes for Somatomedin C is disclosed. Titers of about 900-1000 mg/L have been obtained using the method of the present invention; about two times the titer of prior art processes.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight containing proteins by directly adding amine or quaternary ammonium compounds to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.

Abstract: A polyether and antibiotic material is prepared by forming discrete polyether antibiotic-containing agglomerates which are separable from an aqueous medium, by producing a polyether antibiotic through cultivation of a polyether antibiotic-producing microorganism in a generally aqueous nutrient-containing fermentation broth under conditions wherein at the end of fermentation, a lipid is present in the broth in a sufficient amount to form discrete agglomerates with polyether and antibiotic in the fermentation broth, whereupon the applomerates are separated from the broth.

Abstract: A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.

Abstract: Ring-opened resorcyclic acid lactone derivatives of the formla ##STR1## wherein X is ethylene or ethenylene; Y and Z, which may be the same or different, are methylene, hydroxymethylene or carbonyl; R.sub.1 is hydrogen or lower alkyl of from 1 to about 6 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, hydroxyl, halogen, nitro, amino or a radical selected from the group consisting of --R', --OR', --COOR' and --OCOR' wherein R' is lower alkyl of from 1 to about 6 carbon atoms, lower cycloalkyl of from 3 to about 8 carbon atom, alkenyl of from 2 to about 6 carbon atoms, substituted or unsubstituted aryl of from 6 to about 8 carbon atoms, or substituted or unsubstituted aralkyl wherein the alkyl portion contains from 1 to about 6 carbon atoms and the aryl portion contains from 6 to about 8 carbon atoms. These compounds are useful as growth-promotants in food-producing animals.

Abstract: A method of producing pure and dense amorphous fused synthetic silica. Silica of desired purity is wet pelletized or agglomerated to form particles having an average particle size of between about 5 and 2500 microns. These particles are calcined to volatilize impurities and increase density to at least about 0.9 g/cm.sup.3. Calcined particles are classified by size or reduced in size if desired or needed by grinding in such a way that the purity of the product is maintained.

Abstract: The proteins somatotropin and prolactin are administered to animals in amounts of from about 0.1-24 mg/animal/day to stimulate the immune system by increasing the production of macrophages and augmenting the oxidative metabolism of macrophages. The activated macrophages combat infectious disease causing agents such as viruses, bacteria, fungi, protozoa, helminths, and the like and thus are effective in preventing and treating diseases caused by those agents.

Abstract: Porcine prolactin (pPRL) is administered to poultry in dosages of from about 1-500 ug/kg/day, preferably 10-100 ug/kg/day, to promote growth by improving the rate of weight gain and/or increasing feed utilization efficiency.

Abstract: Somatotropin is administered to food producing animals in the finishing stage of growth to increase fertility by increasing embryonic survival and litter size during the reproductive stage of growth.

Abstract: A device for the continuous administration of a diffusible agent having a relatively rapid rate of diffusion and a diffusible agent having a relatively show rate of diffusion comprises:a wall, formed at least in part by a porous membrane, which surrounds and defines a reservoir, the reservoir comprising:(a) a compartment which comprises the agent having the relatively slow rate of diffusion, wherein said compartment is in direct contact with the porous membrane part of the wall and(b) at least one compartment which comprises the agent having the relatively rapid rate of diffusion, wherein said compartment is not in direct contact with the porous membrane part of the wall and is separated from the compartment comprising the agent having the relatively slow rate of diffusion by a porous partition, such that when said device is exposed to said fluid medium, said agents will diffuse through the porous membrane part of said wall at a substantially steady rate for a prolonged period of time.

Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.

Abstract: A pelletized feed supplement is supplied which effectively increases productivity of animals fed high acid producing diets. The pelletized feed supplement can also be used to neutralize stomach acid of humans and to maintain a proper electrolyte balance. A method is taught of producing the pelletized feed supplement which results in a buffering agent which is dissolved gradually, and has a high buffering capacity.

Abstract: 6' Carbamate esters of zearalanol and its derivatives are used to promote growth in ruminants. The compounds have the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R is NH-Y, where Y is an alkyl group having from 1-6 carbon atoms or a five-membered or six-membered ring; N(C.sub.n H.sub.2n+1).sub.2, where n is an integer from 1 to 6; or a five-membered or six-membered heterocyclic ring having one N heteroatom and up to one other heteroatom selected from the group consisting of N, S, and O heteroatoms.

Abstract: A device for the continuous administration of a beneficial agent to a living being at a substantially steady rate which comprises:(a) a body fluid-contacting layer which comprises a dispersion of an agent which is substantially soluble in the body fluid and a solid matrix material, said matrix material comprising a polymer which is substantially insoluble in said body fluid, and(b) a non-body fluid-contacting layer which comprises said beneficial agent,wherein said body fluid-contacting layer is compression molded to said non-body fluid contacting layer.

Abstract: A method for preparing a dried protein product, such that the bioactivity and potential for solubility of the protein are substantially maintained when said product is administered to a living being and contacted with body fluids of said being, which comprises:(a) forming an aqueous solution comprising a mixture of said protein and an ionic detergent and(b) drying said protein-detergent mixture, wherein a sufficient amount of detergent is mixed with said protein in step (a) to substantially fully coat said protein.

Abstract: A process for purifying lysocellin which comprises mixing lysocellin solids with sufficient halogen acid to convert fatty acid ester salt impurities into water-soluble metal halogen salts and water-insoluble free fatty acids and to convert lysocellin salts into water-soluble metal halogen salts and water-insoluble lysocellin acid, separating the halogen salts from the lysocellin acid and fatty acid solids, mixing the lysocellin acid and fatty acid solids with sufficient caustic reagent to convert free fatty acids into water-soluble alkali metal salts and to convert lysocellin acid into a water-insoluble alkali metal lysocellin salts, and separating the water-soluble fatty acid alkali metal salts from the alkali metal lysocellin solids.

Abstract: A microorganism of the genus Pseudomonas (ATCC 53716) metablizes cinnamate to produce acetophenone in a receoverable quantity upon fermentation in an aqueous nutrient medium containing cinnamate as a carbon source and, optionally, assimilable sources of nitrogen and inorganic substances.

Abstract: Apparatus for typically delivering a measured quantity of liquid to a small animal comprising:a spray nozzle for producing an atomized stream of liquid;a syringe in fluid communication with the spray nozzle for delivering a measured quantity of the liquid from a liquid source to the spray nozzle;means for actuating the syringe to deliver the measured quantity of liquid activated by a compressed air signal from a compressed air source;means for regulating the compressed air signal to deliver to the spray nozzle a portion of the compressed air signal for atomizing the measured quantity of liquid; andmeans for transmitting the compressed air signal simultaneously to the actuating means and to the regulating means.

Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [X.sup.3, Y.sup.8, Z.sup.25, Nle.sup.27 ]-hGRF(1-A)--B, wherein X, Y and Z are selected from the group consisting of Asn and Asp, A has a value from 29-44, and B is NH.sub.2 or OH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).