Abstract: An electric booster according to the present invention comprises a booster piston disposed around an input piston so as to movable relative to the input piston. The booster piston and input piston also serve as a primacy piston of a tandem master cylinder. A brake fluid pressure is generated in the tandem master cylinder by an input thrust force provided from a brake pedal to the input piston and a booster thrust force provided from the electronic actuator to the booster piston. In this electric booster, a slide hole is formed through the secondary piston of the tamed master cylinder in the axial direction therefore, and a rod member is slidably disposed through the slide hole. When the fluid pressure is not increased in the primary pressure chamber, due to the fluid pressure in the secondary pressure chamber, the rod member comes to abut against the input piston, and a reactive force in the secondary pressure chamber is returned to the brake pedal.

Abstract: Disclosed are a crystallizing method of doxorubicin hydrochloride from a doxorubicin hydrochloride-containing solution, particularly a method for carrying out the crystallization under a condition of 40° C. or higher, and a doxorubicin hydrochloride crystalline aggregate having particularly an excellent solubility in water.