Patents Represented by Attorney Wendy E. Rieder
  • Patent number: 5705499
    Abstract: Disclosed are novel 8-arylalkyl-5,11-dihydro-6H-dipyrido?3,2-b:2',3'-e!?1,4!diazepines. These are useful in the treatment of HIV-1 infection.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: January 6, 1998
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Charles L. Cywin, MaryAnn Hoermann, Janice M. Klunder
  • Patent number: 5696123
    Abstract: The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Horst Dollinger, Gerd Schorrenberg, Hans Briem, Birgit Jung, Georg Speck
  • Patent number: 5688802
    Abstract: The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: November 18, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Walther, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz Josef Kuhn, Erich Lehr
  • Patent number: 5686496
    Abstract: The new compound of formula ##STR1## may be prepared by conventional methods and used therapeutically as an LTB.sub.4 -receptor antagonist.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Armin Fugner, Hubert Heuer, Christopher Meade
  • Patent number: 5684029
    Abstract: The invention relates to benzimidazoles of general formula ##STR1## wherein R.sub.1 to R.sub.4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiotensin antagonists.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: November 4, 1997
    Assignee: Karl Thomae GmbH
    Inventors: Berthold Narr, Norbert Hauel, Jacques Van Meel, Wolfgang Wienen, Michael Entzeroth, Uwe Ries
  • Patent number: 5677304
    Abstract: The invention relates to the use of 9-amino-pyridazino-?4',5':3,4!pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerative colitis and Crohn's disease, and for producing agents having an antiproliferative activity. The definitions of substituents R.sub.1 to R.sub.9 are given in the specification. The invention also relates to new compounds of general formula I which are also defined in the specification and their use as cerebroprotective agents.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: October 14, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Patent number: 5675005
    Abstract: This invention relates to a process for preparing xanthine derivatives of formula I: ##STR1## characterized in that a uracil derivative of formula A or B ##STR2## is dissolved in a suitable organic-aqueous solvent and cyclized in the presence of LiOH.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ulrike Kufner-Muhl, Sven Luttke
  • Patent number: 5672586
    Abstract: Disclosed herein are compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or (1-4C) alkyl, R.sup.2 is (1-4C) alkyl or a therapeutically acceptable salt thereof. The compounds are useful for treating herpes infections.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: September 30, 1997
    Assignee: Bio-Mega/Boehringer Ingelheim Research, Inc.
    Inventors: Jean Andre Gauthier, Neil Moss
  • Patent number: 5663338
    Abstract: The present invention relates to a new and improved process for preparing 2-amino-6-chloropurine comprising the step of reacting guanine in the presence of ammonium sulphate with hexamethyldisilazane. The process of this invention advantageously results in a high yield of 2-amino-6-chloropurine and may be carried out on a laboratory or an industrial scale.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: September 2, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Reiner Ramert, Rainer Sobotta
  • Patent number: 5661157
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: August 26, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Patent number: 5654314
    Abstract: The new compounds of formulaA--O--CO--Z (I)(wherein A and Z are defined as explained in the specification) can be prepared by conventional methods; they are suitable as active substances for pharmaceutical compositions.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: August 5, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Rolf Banholzer, Rudolf Bauer, Richard Reichl
  • Patent number: 5650424
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: July 22, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Thomas Mueller, Johannes Weisenberger, Wolfgang Eisert
  • Patent number: 5648386
    Abstract: The invention relates to the separation of enantiomers of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: July 15, 1997
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Wolfgang Resemann, Adolf Durr, Gunther Engelhardt, John Frances Quirke
  • Patent number: 5645050
    Abstract: In an inhaler for powdered drugs, flat carriers are used which have regular microstructures between which the powder for inhalation is embedded.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: July 8, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Bernd Zierenberg, Dieter Hochrainer
  • Patent number: 5641784
    Abstract: New xanthine compounds of formula I: ##STR1## wherein the substituents are defined herein, which xanthines are useful as adenosine antagonists.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: June 24, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ulrike Kufner-Muhl, Werner Stransky, Gerhard Walther, deceased, Karl-Heinz Weber, Helmut Ensinger, Franz Josef Kuhn, Gunter Schingnitz, Erich Lehr
  • Patent number: 5633002
    Abstract: The invention relates to an implantable biodegradable system for releasing active substance.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: May 27, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Stricker, Gunther Entenmann, Otto Kern, Michel Mikhail, Bernd Zierenberg
  • Patent number: 5627272
    Abstract: A method of preparing sugar acetonides, such as for example 1,2:5,6-Di-O-isopropylidene-.alpha.-D-glucofuranose, by reacting the corresponding sugar, e.g. D-(+)-glucose, with acetone in the presence of a Lewis acid and a carboxylic acid derivative of general formula ##STR1## wherein X is a leaving group which may be readily replaced by a hydroxyl group.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: May 6, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Rainer Sobotta, Franz Dietrich Klinger, Heinrich Schneider
  • Patent number: 5618814
    Abstract: The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula ##STR1## (wherein R.sub.a, R.sub.b and R.sub.c are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the physiologically acceptable salts thereof, which have, inter alia, valuable pharmacological properties, particularly in chemotherapy a sensitizing effect on resistant tumors, the use thereof and processes for preparing them.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: April 8, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Armin Heckel, Uwe Bamberger, Annerose Mauz
  • Patent number: 5616717
    Abstract: Racemic mixtures of 1-(S,R)-(2-pyridyl)-2-cyclohexylethylamine are separated into (+)-(S)-1-(2-pyridyl)-2-cyclohexylethylamine or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine by admixture with (+)- or (-)-3-bromocamphor-8-sulfonic acid. 1-(S)-(2-pyridyl)-2-cyclohexylethylamine is an intermediate in the preparation of leukotriene biosynthesis inhibitors.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: April 1, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Karl G. Grozinger
  • Patent number: 5614519
    Abstract: Angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: 4'-[(2-n-propyl-4-methyl-6-(1-(2-N-morpholinoethyl)-imidazol-4-yl)-benzimi dazol-1-yl)-methyl]-biphenyl-2-carboxylic acid.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 25, 1997
    Assignee: Karl Thomae GmbH
    Inventors: Norbert Hauel, Berthold Narr, deceased, Uwe Ries, Jacobus C. Antonius van Meel, Wolfgang Wienen, Michael Entzeroth