Abstract: The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzirnidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to alkylammonium salts of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and an alkylamine with formula NR1R2R3, wherein R1 is a linear, branched, or cyclic C1-C12-alkyl group, and R2 and R3 are hydrogen. The present invention also relates to a process for preparing crystalline salts, a pharmaceutical preparation, and a method for treatment of gastric related disorders by administering the compound of the invention.

Abstract: An expandable stent comprised of a plurality of helical segments is disclosed. In one embodiment, the stent is generally cylindrical in shape having a cylindrical axis, and comprises a first and second set of helical segments. The helical segments in the first set are substantially parallel and have a first pitch forming a first helical angle with respect to the cylindrical axis. The helical segments in the second set are also generally parallel to each other and form a second pitch that differs from the first pitch, thereby forming a second helical angle with respect to the cylindrical axis. In an alternative embodiment, the stent comprises one set of helical segments and a plurality of circumferential elements that are joined together by the helical segments to form a plurality of cylindrical elements which are joined together to form a stent body. The stent may also have endzones.

Abstract: The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to adamantan ammonium salt of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and adamantan amine. The present invention also relates to a process for preparing the compounds of the invention, a pharmaceutical preparation and a method for treatment of gastric related disorders by administering the compounds of the invention.

Abstract: The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough.

Abstract: A method for debugging flowchart based computer programs for industrial controllers, in particular motion controllers, wherein suspend commands are assigned to the graphical elements. Through the use of a task control mechanism in the run time system, the user may debug the program on the flowchart level, using a single-step mode and/or a breakpoint mode.

Abstract: Content is generated on a host system based on real-time data from a controlled process collected over the internet from a customer's client automation system, such as a machine tool control system. The client system may request content from a host website. Instructions associated with the requested content, which may be in the form of software to be run on the client, is delivered to the client via download over the internet. The client, executing the software, captures real-time data associated with a controlled process and transmits it to the host, where content based on the data can be generated for the client and/or its owner. Data gathered by the host, and content generated on the basis of the data, may be made accessible to machine tool manufacturers. Also, data received by the host is associated with an identifier defined for each client system. A historical database for given client equipment can thereby be created.

Abstract: There are provided novel compounds of formula (I) wherein A, R1, R3, R4, R5, T, U, V, W, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory diseases, pain and CNS diseases.

Abstract: The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.

Abstract: The invention relates to a stable medicament for oral administration which comprises (a) a core which contains an active ingredient selected from Omeprazole, Lansoprazole and Pantoprazole, together with customary pharmaceutical adjuvants, (b) an intermediate layer applied onto the core, and (c) a gastric juice-resistant outer layer. The intermediate layer in (b) is formed as a reactive layer in which a gastric juice-resistant polymer layer material partially neutralized with alkali with cation exchange capacity is present. Further, a method for the production of the stable medicament is disclosed.

Abstract: The invention relates to novel compounds having the general formula: (I) and arc useful as selective ER-? ligands in the treatment or prophylaxis of Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis cardiovascular disease, rheumatoid arthritis or prostate cancer.

Abstract: A sorting apparatus has at least two sorter cells arranged substantially one above the other. Sorter cells are fitted to a driving unit for moving the sorter cells from a horizontal loading plane to a horizontal discharge plane, both of which are assigned to the sorter cells. A vertical distance between the sorter cells is equal to the vertical distance between two loading planes arranged one above the other and to the vertical distance between the upper and lower plane of at least a first and a second pair of discharge planes arranged one above the other.

Abstract: The invention provides a prosthesis structure for anchorage to the joint end of an articulatory part of a joint in a human or animal body which comprises an engagement element which presents a flat or a substantially flat engagement surface for engaging with a complementary joint end surface provided at the joint end and an elongate fixture connected to and spaced from the engagement surface for insertion into a complementary bore provided at the joint end at a distance from the joint end surface. The invention further provides that the elongate fixture forms an acute angle with the engagement surface.

Abstract: A device comprising a housing in the shape of a fashion accessory, the housing having a hollow interior, a top portion, and a bottom portion, wherein the hollow interior extends from the bottom portion to the top portion of the housing. A light source module is removeably attached to the top portion of the housing and extends substantially downward within the hollow interior toward the bottom portion. A handle is attached to the top portion of the housing, wherein the handle secures the device to a member within an article having substantially the same shape as the housing, wherein the device illuminates the article interior.

Abstract: A process for the manufacture of omeprazole or esomeprazole from pyrmethyl alcohol via pyrmethyl chloride and pyrmetazole characterized in that the whole reaction sequence is carried out without any isolation or purification of intermediates. Further, the reaction is carried out in a solvent system common for the whole reaction sequence and inert to the reactants formed during the process and used in the process and comprises a water immiscible organic solvent and a specified amount of water.

Abstract: A method for treating a disease associated with the estrogen receptor-?, comprising the step of administiering a therapeutically-effective amount of a compound that satifies the equation: Ki?A/Ki?A>25, optionally having general structure (I).

Abstract: The present invention relates to a filter device, especially for a fluidised bed system and particularly for use in the pharmaceutical industry, for separating particles larger than a separating grain from an amount of particles in a fluid flow. The filter device includes a housing and at least one filter portion. A part of the housing is mounted for rotational movement, and the filter portion is provided in the housing, whereby the filter portion is movable upon rotation of the housing. The present invention also relates to a method for separating particles using such a filter device.

Abstract: The present invention relates to a sample presentation apparatus for use in analyzing equipment for pharmaceutical products, for example solid dosage forms such as a tablet, a pellet or a capsule. The invention further relates to a method for presentation of samples to the analyzing equipment. Samples are sequentially fed through at least one predetermined analyzing position (6) wherein at least one measuring radiation beam irradiates the sample (14) when it is located in the analyzing position characterized in that there is at least one two-piece means (9, 39) for temporarily fixing each sample at said analyzing position (6), the two-piece means comprises a first and a second sample holding part arranged at the analyzing position in which the two-piece means is adapted to move between an open position wherein a sample is provided for analysis, and a closed fixing position wherein a sample is analyzed.

Abstract: An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a colelcted sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).

Abstract: The present invention is directed to a method for determining actual states of a number of adjusting elements. A position of an additional member relative to a basic member can be set by means of a number of adjusting elements. In order to determine the actual states of the adjusting elements, the additional member is firstly fixed mechanically relative to the basic member in such a way that it has only one degree of freedom. It is then possible to describe the position of the additional member relative to the basic member by means of a single scalar variable. The position of the additional member is then changed. Changes in state effected by the change in position of the additional member are detected, and the actual states of the adjusting elements are determined therefrom.