Abstract: The present invention relates to a novel crystalline form of the compound (S)-2-ethoxy-3-[4-(2-{4-methanesulfonyloxyphenyl}ethoxy)phenyl]propanoic acid, shown by formula (I), or a pharmaceutically-acceptable salt thereof, and solvates thereof. The invention also concerns methods of treating one or more metabolic disease conditions, particularly those associated with Insulin Resistance Syndrome, and the use of a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof, in the manufacture of a medicament for use in one or more of said conditions. The invention further concerns pharmaceutical compositions containing a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof, as active ingredient, as well as processes for the manufacture of a crystalline form of the compound, or a pharmaceutically-acceptable salt thereof, or a solvate thereof.

Abstract: The present invention relates to human bile salt-stimulated lipase (BSSL) obtainable from transgenic sheep. The invention further relates to transgenic sheep whose germ cells and somatic cells contain a recombinant nucleotide molecule comprising a nucleotide sequence encoding for human BSSL. The invention also relates to methods for producing said transgenic animals, as well as to methods for producing human BSSL derived from transgenic animals. In addition, the invention provides the use of compositions comprising BSSL in the treatment of diseases relating to exocrine pancreatic insufficiency, and for improvement of the utilization of dietary lipids in preterm born infants.

Abstract: A new oral IR formulation in solid form for a low molecular weight thrombin inhibitor having pH dependant dissolution, characterized in that the formulation comprises a filler or a combination of fillers having disintegrant properties in an amount higher than 35% w/w of the formulation.

Abstract: The invention relates to a method for producing a pulse trail for at least one target whose actual position is represented in a continuous manner in a radar image of a radar device. In order to improve said method, wherein the pulse trails are represented on the radar screen in a highly visible manner for a viewer without any overcrowding of the radar screen when a plurality of targets that should be displayed simultaneously are present, the actual target position can be seen by means of a plurality of pixels that cover a continuous surface of the radar image and prior target positions are represented by a thinning out of said pixels that increases according to the chronological status of the respective target positions in the area.

Abstract: The present invention relates to heterocyclic compounds of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.

Abstract: The present invention relates to a novel form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole, known under the generic name omeprazole. More specifically, it relates to a novel crystalline form of the potassium salt of the (S)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole. The present invention also relates to processes for preparing such a form of the potassium salt of (S)-omeprazole and pharmaceutical compositions containing it.

Abstract: Novel salts of N-tert-butylhydroxylamine with lower carboxylic acids are disclosed, together with processes for their preparation. The salts possess advantageous properties that render them useful in synthesis.

Abstract: The invention relates to a cutting guide instrument and method for enabling high-precision resection of the head (caput femoris) (8) of the neck (5) of a human femur (collum femoris) at a predetermined cutting angle (&agr;c) to the femoral shaft (9) and on a predetermined cutting level (Lc) with respect to the proximal end of the caput (8). A support part (11) is fixed to the femur during the resection. A longitudinal guide carrier (12) is supported by the support part (11) and is aligned along the femoral collum (5) at said predetermined cutting angle (&agr;c) to the femoral shaft (9). A cutting guide (13) is supported by and movable along the axis (D—D) of the guide carrier (12) to a cutting position corresponding to the predetermined cutting level (Lc). The invention also relates to the use of the instrument for performing such resection.

Abstract: The present invention relates to dried preparations containing a class III antiarrhythmic compound in the form of a crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic compound in the form of a salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]-nonane-3-carboxylic acid, 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1-dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparations, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhytmia.

Abstract: A method for therapeutic or prophylactic control of Acquired Immunodeficiency Syndrome (AIDS) in which an effective dose of phosphonoformic acid or a therapeutically-acceptable salt thereof is administered to a patent.

Abstract: A mixing apparatus for and a method of supplying a mixture having a required homogeneity, the mixing apparatus comprising: a mixing device (1; 101) for mixing a plurality of materials, the mixing device (1; 101) including a mixing vessel (7; 107) and having at least one inlet port (8, 9; 108, 109, 110) and an outlet port (11; 111); a supply line (19; 119) connected to the outlet port (11; 111) of the mixing device (1; 101); and at least one measuring device (23, 25, 27; 123, 125, 127) for measuring on-line at at least one point in the supply line (19; 119) the composition of the mixed material passing in use through the supply line (19; 119).

Abstract: The use of chitosan and a polysaccharide immobilized thereto selected from heparin, heparan sulphate and dextran sulphate for the manufacture of an agent capable of preventing or substantially reducing undesirable adhesion of damaged tissue with adjacent or surrounding tissues in connection with wound healing; and a process for the use of such agent.

Abstract: The invention relates to a laminated fabric heater element, heater and a process for manufacturing the heater element and heater. The heater comprises an electrically conductive fabric layer attached to bus bars, is sandwiched between two thermoplastic films forming a heater assembly. In the process making the heater element or heater, the layers of the heater assembly by consolidating the layers of films and fabric into a single sheet heater without the use of adhesive resins. The heater can be made of variable geometry, electrical supply voltage and power, and can withstand more mechanical, chemical, ultraviolet radiation and other environmental stresses than prior art heaters.

Abstract: A portable/hanging feminine sanitary napkin utility bag is provided for the storage and retrieval of feminine sanitary napkins consisting of a rectangular main housing with front, back, left, right and bottom panels, a top access opening closeable by a pivoting lid and an adjoining peripheral rim is horizontally attached to the uppermost edge of the back panel with a side access opening on the lowermost part of a side panel that is closeable by a pivotal flap allowing for the retrieval of one feminine sanitary napkin at a time and a pocket on the opposing side panel and back panel that provide for the storage of feminine supplies, contraceptives, panties or the like with a strap that straddles above the rectangular main housing and is affixed slightly remote from the uppermost edge of the side panels, allowing for portability and hanging.

Abstract: The invention provides a process for crystallization of amorphous and/or meta-stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid containing an anti-solvent and a solvent. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceutically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.

Abstract: The invention provides the use of certain succinimide compounds in the treatment of mycobacterial diseases.

Abstract: The present invention relates to a method of inhibiting the activity of the HIV virus in a human comprising administering to the human an effective dose of phosphonoformic acid or a therapeutically effective salt thereof.