Abstract: Highly purified and recombinantly produced polypeptides and proteins can be provided to a patient to treat systemic disorders using a metered dose inhaler (MDI). The polypeptides and proteins are solubilized in reverse micelles formed from the surfactant in the MDI propellant. By controlling the molar ratio of water to surfactant, the amount of polypeptide or protein solubilized in the reverse micelles can be controlled, thereby providing an accurate dosing mechanism. In addition, controlling the molar ratio of water to surfactant also can adjust the size and shape of the reverse micelles which will affect the degree and rate of penetration of the lung mucosa for delivery of the drugs to the patient's blood stream. Proteins which may particularly benefit from the solubilization and systemic delivery process include calcitonin, oxytocin, and insulin.

Abstract: An improved railroad coupler mount (18) secures end of train signalling and monitoring equipment (40) to the coupler head (10) of the last car in a train. The coupler mount (18) is secured to the coupler head (10) by a banana shaped arm (20) which extends through relief holes (14a and 14b) in the guard arm side (12) of the coupler. A swivel toggle (22) positioned at the end of the arm (20) is pivoted to a perpendicular orientation relative to the arm (20) after it has been inserted through the relief holes (14a and 14b). A tightening screw (28) turned by knob (26) draws the arm (20) back out of the relief holes (14a and 14b) and causes the swivel toggle (22) to bear against the sidewall of the coupler head (10). A bulge (38) in the arm (20) is braced tightly against an inside wall of the coupler head (10) after tightening the arm (20).

Abstract: A solid-state telephone trunk interface circuit provides high isolation between a central office and telephone equipment. Opto-isolator transistors and a transformer are used to isolate the central office and the local equipment portions of the circuit. A switching transistor (Q4) is connected between a ring connector (3) and turned on and off via an opto-isolator transistor connected to a control connector (9). A ring detector (11) comprising a first diode bridge is connected between tip and ring connectors (2 and 3) via an opto-isolator transistor to a ring signal connector (13). First and second parallel and opposite sign line condition detectors are respectively connected between tip and ring connectors and via opto-isolator transistors to battery-reverse and battery-forward signal connectors (19 and 17). The voice circuit includes a second diode bridge connecting tip and ring connectors to a first winding of a transformer (T1).

Abstract: A method for controlling arrivals to servers, comprising: regulating arrivals, by initiating a processor generating arrivals or by re-routing or turning away arrivals; measuring durations of service; computing and updating time statistics, including mean, minimum, maximum expected and standard deviation of duration of service thereby estimating expected duration of service; measuring transit times from the point of regulating arrivals to start of service and thereby estimating expected transit times; measuring a ratio of numbers of service initiations to numbers of arrivals at the point of regulating arrivals; recording starting time of each current service; noting present time; comparing present time to starting time, and thereby determining time in progress for each service; comparing time in progress to expected duration of service, and estimating time remaining in service for each customer currently in service; comparing estimated time remaining in service to estimated transit time from the point of regul

Abstract: A user interactive mass storage data access system includes a personal computer (10) and a simulated book (30). A mass storage device, such as a compact disk (CD) read only memory (ROM) (22), is connected to the personal computer, and the computer and the simulated book are connected by an infrared (IR) data communications link including IR transceivers (26, 48). The simulated book includes a display screen (34) and a microprocessor (43) with memory (44, 46). The microprocessor is programmed for storing data received and decoded by its IR transceiver (48) in memory (46) and responsive to user input for displaying a page of data on the display screen. In addition, the microprocessor is programmed to cause its IR transceiver (48 l ) to transmit to the IR transceiver (26) connected to the personal computer (10) a data request command, and the personal computer is in turn programmed to transmit data from the CD ROM (22) to the simulated book (30).

Abstract: An application program interface for handling full-screen input/output (I/O) operations of a display device in an information handling system, such as a computer system running one or more application programs in conjunction with an operating system. The application program interface first determines characteristics of the display device in response to a request from an application program prior to performing a full-screen I/O operation, and provides these characteristics to the application program so that the application program can provide a buffer, and if an output is to be performed, construct a valid data stream for the display device. Then the application program interface builds a parameter list in response to a request from an application program to actually perform the full-screen I/O operation.

Abstract: A computer aided drafting (CAD) procedure presents, for a three dimensional (3D) object to be modeled in a general purpose computer, dimensional and tolerance parameters appropriate to changes of view or parameters. The procedure requires but one model, the three dimensional solid model, for producing both dimensioned displays of the model and dimensioned drawings of views of the model. Dogleg extension lines are used to express 3D dimensions without ambiguity. These dogleg extension lines facilitate the presentation of information on paper or on a display screen and permit convenient alteration of presentations of 3D illustrations, with automatic correction of dimension and tolerance presentation. The operator of the CAD system enters dimension and tolerance information on a plan or elevation view, and this information is automatically converted to an appropriately corrected and presented axonometric presentation.