Abstract: A rational method for obtaining a novel molecule capable of a desired interaction with a substrate of interest comprising selecting hosts or replicators which encode said novel molecules based upon cell or replicator growth caused by the desired interaction of the novel molecule and a selection molecule expressed by said host.

Abstract: Eyewear which provides a visual stimulation to the wearer while permitting the wearer to maintain a degree of normal sight. The eyewear may include a frame securing a first viewing zone which is responsive to an external signal for modulation of a visual characteristic thereof and a second viewing zone which permits the wearer to maintain a degree of normal sight through that zone. Alternatively, a single zone is responsive to an external signal while nevertheless permitting the wearer to maintain an degree of normal sight.