Abstract: A method and apparatus is disclosed for determining the oxidative stability of pure lipids or lipids incorporated into complex matrices containing other, non-lipid ingredients. An exemplary test system includes a first container adapted to contain the sample and a heater for heating the sample to make it give off an effluent gas. A second container contains a collection fluid through which the effluent gas can be passed. A sensor within the second container measures pH, acetate, ammonia, and/or formate. An optional computation device in communication with the one or more sensors determines a point in time at which the level of one of pH, acetate, formate and/or ammonia changes suddenly.

Abstract: A clot evacuation catheter includes a hollow tubular body disposed within an outer lumen. The tubular body is elongate and includes a selectively rotatable cutting blade disposed within a distal portion thereof to cut clots occluded in at least one opening of the cutting blade. The tubular body also includes a fluid conveying irrigation lumen to deliver fluid to a distal end of the catheter at predetermined times. In an alternative embodiment of the present invention, a hood member extends from the distal portion of the tubular body. The hood member has a distal end that is spaced from, but coaxial with, the distal portion of the tubular body through a side portion of the hood member.

Abstract: Process for fabricating a thin film head for high track density recording defines an easy axis parallel to the track in the narrow poletip without a need of a very high magnetic field in the plating cell. Narrow poletips of equal widths of P1 and P2 are obtained. The process includes sheet depositing a magnetic layer, then depositing a sheet of gap material, and then depositing a sheet of another magnetic layer. This operation can be done either by a vacuum technique or by an electroplating process. If it is done by vacuum processing, all the three depositions can be done in one pumpdown. Since the sheet magnetic films are deposited, the demagnetizing field is very small, and a small orienting field is necessary unlike the large field required in the prior art.

Abstract: Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula ##STR1## where X is S or Se; Y is I, F, Cl, Br, methoxy, benzyl, selenenylphenyl, or thiophenyl, and R.sub.1 is an acyclo tail having the general formula ##STR2## where R.sub.2 is H, CH.sub.2 OH or CH.sub.2 NH.sub.2 ; R.sub.3 is OH, NH.sub.2, or OCOCH.sub.2 CH.sub.2 CO.sub.2 H; and R.sub.4 is O, S, or CH.sub.2.The compounds can be used in pharmaceutical compositions, along with various chemotherapeutic agents to increase the efficacy of the treatment. These compounds can also be used in methods of treating patients by coadministering or sequentially administering the enzyme inhibiting compounds with a chemotherapeutic agent effective to treat cancers, or viral, fungal, bacterial, or parasitic infections. The compounds have further utility in enhancing imaging.

Abstract: A method and apparatus for testing flow control valves is disclosed. Specifically, the flow control valves of anesthesia machines are tested. The method contemplates the application of positive and negative air pressure to the valve being tested. If the valve is functioning properly, the valve will open or seal as expected. An apparatus is disclosed which enables a technician to apply either negative or positive pressure to the flow control valve and determine whether the valve is opening and sealing properly. The apparatus includes a pump for creating the air pressure and a fitting adapted to sealingly engage the port of the valve. The apparatus is simple to use and reduces the risk of transmitting disease.

Abstract: A process is provided for catalytically reducing imines, oximes, hydrazones and related compounds. Moreover, there is provided a process for the catalytic asymmetric reduction of imines, oximes, hydrazones, and the like, using enantiomerically enriched catalysts, to provide chiral amine reaction products which are enriched in one enantiomer. Catalytic asymmetric reduction can also be carried out using an achiral precatalyst in combination with aThe U.S. Government has rights in this invention pursuant to NIH Grant Number GM 34917.

Abstract: A process is provided whereby organic carbonyl substrates, including esters, ketones and amides, are reduced in a reaction with a silane reducing reagent and a catalyst. Effective catalysts broadly include those which consist of a group 4, 5 or 6 metal which either: a) is in less than its maximum oxidation state or is capable of being converted to a complex in less than its maximum oxidation state; and/or is a group 4, 5 or 6 metal hydride. Exemplary catalysts include titanium-containing catalysts such as (bis trimethylphosphine) titanocene, trimethyl phosphine adduct of a (hydrido) silyl complex of titanocene, titanocene dichloride and titanocene monochloride.

Abstract: A process is provided for the catalytic asymmetric reduction of ketones to provide alcohol reaction products which are enriched in one enantiomer. The asymmetric reduction is accomplished utilizing an achiral metal precatalyst in combination with an optically active additive.

Abstract: A process is provided whereby organic carbonyl substrates, including esters, lactones, ketones, amides and imides are reduced in a reaction with a silane reducing reagent and a catalyst. Exemplary catalysts include metal alkoxides and metal aryloxides.

Abstract: A method of forming a polycrystalline film, such as a diamond, on a foreign substrate involves preparing the substrate before film deposition to define discrete nucleation sites. The substrate is prepared for film deposition by forming a pattern of irregularities in the surface thereof. The irregularities, typically craters, are arranged in a predetermined pattern which corresponds to that desired for the location of film crystals. The craters preferrably are of uniform, predetermined dimensions (in the sub-micron and micron size range) and are uniformly spaced apart by a predetermined distance. The craters may be formed by a number of techniques, including focused ion beam milling, laser vaporization, and chemical or plasma etching using a patterned photoresist. Once the substrate has been prepared the film may be deposited by a number of known techniques. Films prepared by this method are characterized by a regular surface pattern of crystals which may be arranged in virtually any desired pattern.

Abstract: Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the toxicity of pyrimidine nucleoside analogues during the treatment of retroviral diseases, such as AIDS, and that uridine phophorylase inhibitors are particularly effective in maintaining the necessary levels of uridine within such cells. A treatment for AIDS-type diseases is disclosed in which a pyrimidine nucleoside analogue and a uridine phosphorylase inhibitor are co-administered either simultaneously or sequentially to treat the viral infections and protect or rescue uninfected cells in the afflicted subject. This combination therapy also can be supplemented by direct administration of uridine.

Abstract: An apparatus is disclosed for housing radioactively and biologically contaminated waste materials during treatment thereof to inactivate the biological contaminants and render the wastes more suitable for disposal in a solid landfill. The apparatus is nonporous and thermally resistant. Additionally, the apparatus features at least one opening within which is disposed a filter for entrapping any radioactive compounds contained in gases exiting the apparatus during the treatment. The apparatus is used in conjunction with an autoclaving procedure which inactivates the biological contaminants while preventing volatile radioactive compounds from escaping into the environment.

Abstract: An apparatus for housing radiation-emitting items to be incubated, such as radio-labeled cell cultures, in order to prevent contamination of the interior of an incubator and the surrounding environment. The apparatus is nonporous and preferably relatively thermally resistant. Additionally, the apparatus features a selectively sealable lid and has at least one opening within which is disposed a filter for entrapping any radioactive compounds contained in gases exiting the apparatus during incubation. The apparatus is used in conjunction with known incubation procedures of radiolabelled cell cultures or other items.

Abstract: An apparatus is disclosed for housing radioactively and biologically contaminated waste materials during treatment thereof to inactivate the biological contaminants and render the wastes more suitable for disposal in a solid landfill. The apparatus is nonporous and thermally resistant. Additionally, the apparatus features at least one opening within which is disposed a filter for entrapping any radioactive compounds contained in gases exiting the apparatus during the treatment. The apparatus is used in conjunction with an autoclaving procedure which inactivates the biological contaminants while preventing volatile radioactive compounds from escaping into the environment.

Abstract: A simple and effective method for producing bulk single and mixed oxide absorbents and catalysts is disclosed. The method yields bulk single oxide and mixed oxide absorbent and catalyst materials which combine a high macroporosity with relatively high surface area and good mechanical strength. The materials are prepared in a pellet form using as starting compounds, calcined powders of the desired composition and physical properties these powders are crushed to broad particle size distribution, and, optionally may be combined with an inorganic clay binder. The necessary amount of water is added to form a paste which is extruded, dried and heat treated to yield and desired extrudate strength. The physical properties of the extruded materials (density, macroporosity and surface area) are substantially the same as the constituent powder is the temperature of the heat treatment of the extrudates is approximately the same as the calcination temperature of the powder.

Abstract: A compact, electrochemical converter can be achieved using thin plates of electrolyte and interconnector. Impermeable, straight, thin plates of solid-oxide electrolyte are fabricated by high energy plasma spray methods under controlled temperature conditions. Thin sheets of nickel alloys or silicon carbide or platinum alloys can be used to form the interconnector. The electrolyte and interconnector plates can be assembled into a converter stack at an elevated temperature such that upon cooling and during subsequent operational temperature excursions, the electrolyte plates will remain in compression. The stacks can be connected together to form modules which can be used as stand-alone electricity generators or used in combined cycle, cogeneration and gasifier systems.